Pain Modulation Flashcards
What is pain
An unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage
What are the dualities of pain
Physiological experience and psychological experience
What are the goals of pain treatment (3)
- Resolve the underlying pathology causing pain
- Modify the patient’s perception of pain
- Allow the patient to maximize their functional abilities
What are the categories of pain (4)
- Nociceptive
- Neuropathic
- Psychogenic
- Carcinogenic
What is the function of pain (3)
- Warning for withdrawal
- Alerts that something is wrong
- Protective function
What are the 2 types of nociceptive pain
- Somatic
2. Visceral
What is somatic pain
Activation of nociceptors found in most body tissue
What is visceral pain
Activation of nociceptors found in viscera
Is visceral pain referred or localized
Referred
Is all of the viscera sensitive to pain
Nope
What are the types of neuropathic pain (2)
- Peripheral
2. Central
What is psychogenic pain
Pain that originates from nonorganic sources and is associated with emotional, cognitive, and behavioral responses
What are the 4 types of pain
- Acute
- Chronic
- Referred
- Radicular
What is carcinogenic pain
Pain caused by cancerous pathology that is severe
What is acute pain
Combination of unpleasant sensory, perceptual, and emotional experiences that occur in response to noxious stimulus
Characteristics of acute pain (3)
- Time limited
- Persists as long as noxious stimulus persists
- Serve a protective function
What is treatment of acute pain from musculoskeletal injury aimed to (3)
- Facilitate resolution of underlying problem
- Reduce inflammation
- Modify the transmission of pain from periphery to CNS
What is chronic pain
Continuous long term pain of more the 12 weeks after healing would have occurred
What causes chronic pain (2)
- Changes in sympathetic NS, adrenal activity, reduced production of endogenous opioids, or sensitization of primary afferents
- Increased sensitivity to noxious and non-noxious stimuli`
What is referred pain
Pain felt at a location distant from its source
What is radicular pain
Pain originating from an irritated nerve root that follows a dermatomal pattern
What are pain receptors called
Nociceptors
What are the 4 types of sensors
- Mechano
- Thermo
- Noci
- Proprio
What are the 2 categories of peripheral sensory receptors
Superficial and deep
What are the types of mechanoreceptors (4)
- Meissner’s corpuscles
- Pacinian corpuscles
- Merkle cells
- Ruffini endings
What are the 2 types of thermoreceptors
Cold and hot
What are the 3 types of proprioceptors
- GTO
- Pacinian corpuscles
- Ruffini endings
What do meissner’s corpuscles sense
Pressure and touch
What do pacinian corpuscles, merkle cells, and ruffini endings sense
Skin stretch and pressure
What do GTO sense
Change in muscle length and spindle tension
What do deep pacinian corpuscles sense
Change in joint position and vibration
What do ruffini endings sense
Joint end range and heat
Is the life of a sensor long or short
Short
Why is the life of a sensor short
The brain decides if we need more or less receptors to modulate sensitization of stimuli
True or False:
Nociceptors respond to all manners of stimuli
True
When does a nociceptor send a signal
When it is stimulated enough
What is the pain threshold
The number of receptors needed to fire
What are the 3 fibers in the peripheral nerve afferent fibers
- A beta fibers
- A delta fibers
- C fibers
What is the diameter, myelination and speed of A beta fibers
Diameter: 6-12 um
Myelinated
Speed: >30 m/sec
What is the diameter, myelination and speed of A delta fibers
Diameter: 1-6 um
Myelinated
Speed: 30 m/sec
What is the diameter, myelination and speed of C fibers
Diameter: 1mm
Nonmyelinated
Speed: 1-4 m/sec
What info do A beta fibers transmit (2)
Touch and vibration
What info do A delta fibers transmit (4)
Touch, temperature, pressure, and pain
What info do C fibers transmit (4)
Pain, touch, pressure, and temperature