Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PRNU 228 > Pain and Inflammation > Flashcards

Pain and Inflammation Flashcards

1
Q

Aspirin (ASA) class

A

First gen NSAIDs COX inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Aspirin (ASA) therapeutic use

A

relieves mild to moderate pain, fever, inflammation, dysmenorrhea
reduces risk of TIAs, CVAs, and MIs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Aspirin (ASA) EPA

A

inhibits actions of COX 1 and 2
blocks pain impulses centrally and peripherally
acts on the hypothalamus as antipyretic
suppresses platelet aggregation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Aspirin (ASA) ADRs

A

nausea, epigastric pain, heartburn, GI bleed, hemorrhage, petechiae, bruising

toxicity causes metabolic acidosis, respiratory failure, cardiac collapse

salicylism is toxicity due to chronic use, characterized by dizziness, tinnitus, and mental confusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Aspirin (ASA) contraindications and interactions

A

known bleeding risk
teratogenic
age <18

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Aspirin (ASA) interventions and education

A

take with food
watch for bleeding or hearing loss
avoid alcohol
avoid for a week before surgery or dental procedures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Aspirin (ASA) black box warning

A

risk of reye’s syndrome if given to children or teenagers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

ibuprofen (Advil and Motrin) class

A

First gen NSAIDs COX inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

ibuprofen (Advil and Motrin) therapeutic use

A

Relieves mild to moderate pain, fever, inflammation, dysmenorrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

ibuprofen (Advil and Motrin) EPA

A

: Inhibits the actions of COX-1 & COX-2, but slightly more selective with COX-2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

ibuprofen (Advil and Motrin) ADRs

A

dry mouth, nausea, heartburn, GI ulceration, nephrotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

ibuprofen (Advil and Motrin) black box warning

A

do not give to patients after coronary artery bypass surgery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

ibuprofen (Advil and Motrin) interventions and education

A

take with food
stay hydrated
watch for bleeding
avoid alcohol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

ibuprofen (Advil and Motrin) contraindications and interactions

A

known bleeding risk
teratogenic
renal disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

celecoxib (Celebrex) class

A

second gen NSAIDs Cox 2 inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

celecoxib (Celebrex) therapeutic use

A

treat swelling in joints caused by RA and OA by suppressing inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

celecoxib (Celebrex) EPA

A

Inhibits COX-2 enzyme to decrease inflammation, it does not affect the COX-1 enzyme

protects the lining of the GI tract and does not inhibit clotting factors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

celecoxib (Celebrex) ADRs

A

GI upset, kidney dysfunction, cardio and cerebrovascular events

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

celecoxib (Celebrex) black box warning

A

increased risk for MI and CVA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

celecoxib (Celebrex) contraindications and interactions

A

kidney disease
bleeding disorders
allergy to sulfa
CVA or MI history

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

celecoxib (Celebrex) interventions and education

A

give with food
give 2 hours before magnesium or aluminum based antacids
report chest pain or CVA symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

acetaminophen (Tylenol) class

A

nonopioid analgesic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

acetaminophen (Tylenol) EPA

A

acts on hypothalamus to increase vasodilation and sweating to reduce fever
inhibits COX to decrease pain but does not have anti-inflammatory and anticoagulant effects

24
Q

acetaminophen (Tylenol) therapeutic use

A

reduce fever
decrease minor pain

25
Q

acetaminophen (Tylenol) ADRs

A

hepatotoxicity
hypertension

26
Q

acetaminophen (Tylenol) contraindications and interactions

A

alcohol use disorder
liver and kidney disease

27
Q

acetaminophen (Tylenol) interventions and education

A

do not exceed 4,000 mg in 24 hours
check BP regularly

28
Q

tramadol (Ultram) class

A

centrally acting nonopioid

29
Q

tramadol (Ultram) therapeutic use

A

moderate to severe pain

30
Q

tramadol (Ultram) EPA

A

binds to select opioid receptors and block reuptake of norepinephrine and serotonin in the CNS

31
Q

tramadol (Ultram) ADRs

A

sedation and dizziness
rarely respiratory depression

32
Q

tramadol (Ultram) contraindications and interactions

A

seizure disorders
respiratory depression

33
Q

tramadol (Ultram) interventions and education

A

take with food
only take short term when needed
do not take prior to driving or activities that require mental awareness

34
Q

morphine class

A

opioid agonist

35
Q

morphine therapeutic use

A

moderate to severe pain

36
Q

morphine EPA

A

mimics action of endorphins and enkephalins by binding with mu receptors at opioid receptor sites.

stimulation of opioid receptors causes analgesia, sedation, euphoria, and respiratory depression.

37
Q

morphine ADRs

A

respiratory depression
lightheadedness
dizziness
constipation
abuse or tolerance

38
Q

morphine contraindications and interactions

A

respiratory depression
pregnancy
caution with older adults and infants
renal or kidney disease

39
Q

morphine interventions and education

A

antidote is naloxone
monitor respiratory status
schedule II - highest risk while still legal
take only when needed, short term
do not take before driving
gradual position change
stool softener or laxative

40
Q

buprenorphine (Buprenex) class

A

opioid agonist-antagonist

41
Q

buprenorphine (Buprenex) therapeutic use

A

moderate to severe pain
anesthesia adjunct
treat opioid use disorder

42
Q

buprenorphine (Buprenex) EPA

A

mu receptor antagonist and kappa receptor agonist
fewer mu-related ADRs: resp depression and euphoria
milder analgesic effects

43
Q

buprenorphine (Buprenex) ADRs

A

increased cardiac workload
respiratory depression (less common)
nausea
constipation

44
Q

buprenorphine (Buprenex) contraindications and interactions

A

respiratory depression
acute MI
renal or hepatic disease

45
Q

buprenorphine (Buprenex) interventions and education

A

antidote is narcan, may require repeated dose
monitor respiratory status
schedule IV
take short term only when needed
do not take before driving
change positions gradually

46
Q

naloxone (Narcan) class

A

opioid antagonist

47
Q

naloxone (Narcan) therapeutic use

A

reverse opioid effects, overdose

48
Q

naloxone (Narcan) EPA

A

block opioid receptors, reversing or antagonizing effects of opioids

49
Q

naloxone (Narcan) ADRs

A

ventricular arrhythmias
increase HR and RR
withdrawal symptoms: HTN, vomiting, tremors

50
Q

naloxone (Narcan) contraindications and interactions

A

opioid dependence
cardiac irritability

51
Q

naloxone (Narcan) interventions and education

A

monitor VS
drug can increase pain because it reverses opioids
administer every 2-3 minutes until opioid effects are reversed
observe for nausea, vomiting, tachycardia, and sweating

52
Q

allopurinol (Zyloprim) class

A

antigout/antihyperuricemic

53
Q

allopurinol (Zyloprim) therapeutic use

A

manage signs and symptoms of gout and reduce uric acid concentrations

54
Q

allopurinol (Zyloprim) EPA

A

inhibits the enzyme that converts purines to uric acid, reducing uric acid production

55
Q

allopurinol (Zyloprim) ADRs

A

GI - N/V, diarrhea
bone marrow depression
agranulocytosis

56
Q

allopurinol (Zyloprim) contraindications and interactions

A

interferes with warfarin
bone marrow depression
hepatic or renal dysfunction

57
Q

allopurinol (Zyloprim) interventions and education

A

take after meals
at least 3L fluid per day
report decreased output or cloudy urine
avoid alcohol, meat, fish, asparagus, spinach, peas

PRNU 228 (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions