Lecture Week 6 Heart Failure and Diuretics Flashcards

1
Q

Digoxin (Lanoxin) class

A

cardiac glycoside

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2
Q

Digoxin (Lanoxin) Therapeutic Use

A

management of mild to moderate heart failure in adults and children

also controls the ventricular response rate in adults with chronic atrial fibrillation

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3
Q

Digoxin (Lanoxin) EPA

A

improves the contractility and pumping ability of the heart by increasing calcium and inhibiting sodium and potassium

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4
Q

Digoxin (Lanoxin) ADRs

A

digoxin toxicity - cardiac dysrhythmias

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5
Q

Digoxin (Lanoxin) Interventions and Education

A

give 1 hr prior to antacid
hold for pulse <60
slow IV push >5 mins
monitor serum levels
educate on toxicity symptoms
take at same time - do not skip or double dose

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6
Q

Digoxin (Lanoxin) contraindications and interactions

A

ventricular dysrhythmias, AV block, severe heart disease

higher risk for toxicity in children and older adults

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7
Q

digoxin toxicity

A

dysrhythmias and bradycardia, heart blocks
nausea and vomiting
abdominal pain
blurry, yellow-tinted, vision or halos

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8
Q

reversal agent for digoxin toxicity

A

digibind (digoxin immune fab)

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9
Q

Dobutamine class

A

Inotropic Agent sympathomimetics

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10
Q

Dobutamine therapeutic use

A

severe heart failure, should only be short term use

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11
Q

Dobutamine EPA

A

Beta-1 adrenergic agonist = increased inotropy = increased cardiac output

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12
Q

Dobutamine ADRs

A

tachycardia
dysrhythmias
anginal pain

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13
Q

Dobutamine interventions and education

A

cardiac monitoring
continuous VS
monitor urine output

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14
Q

Dobutamine interactions

A

MAOI and tricyclic antidepressants
general anesthesia

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15
Q

Milrinone class

A

Inotropic Agent
Phosphodiesterase Inhibitor

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16
Q

Milrinone therapeutic use

A

short term for severe heart failure

patients not responsive to Digoxin, diuretics and vasodilators

Bridge to therapy or longer term for palliation of symptoms.

17
Q

Milrinone EPA

A

blocks PDE3 - enzyme that breaks down cyclic AMP = positive inotropic effect

18
Q

Milrinone ADRs

A

ventricular dysrhythmias
hypotension
hypokalemia
anginal chest pain

19
Q

Milrinone interventions and education

A

Continuous monitoring of BP, HR and cardiac rhythm.

Monitoring of electrolytes - K+

Monitor for chest pain

20
Q

Milrinone contraindications

A

Caution: aortic/pulmonary valve issues, acute MI

Renal impairment, history of arrhythmias, electrolyte imbalances, abnormal digoxin levels

21
Q

Furosemide (Lasix) class

A

loop diuretics

22
Q

Loop diuretics other drugs

A

Bumetanide (Bumex)
Torsemide (Demadex)

23
Q

Furosemide (Lasix) therapeutic use

A

used when rapid effects are needed - pulmonary edema

used when renal function is impaired

24
Q

Furosemide (Lasix) EPA

A

Inhibits sodium and chloride reabsorption in the loop of Henle

25
Q

Furosemide (Lasix) ADRs

A

Hypokalemia, hyponatremia, hypochloremia

fluid volume deficit (dehydration)

hypotension - orthostatic hypotension

Hyperglycemia and Hyperuricemia

26
Q

Furosemide (Lasix) interventions and education

A

IV dose administered slowly - 2 min per 20 mg
daily weight
monitor Is and Os
monitor electrolytes
take BP before and after
monitor renal function
report hearing loss or tinnitus

27
Q

Furosemide (Lasix) contraindications

A

caution with electrolyte imbalance and dehydration
caution with other ototoxic meds
can increase lithium toxicity

28
Q

Hydrochlorothiazide (Microzide) class

A

thiazide diuretics

29
Q

Hydrochlorothiazide (Microzide) therapeutic use

A

mild-mod HTN
edema d/t HF
nephrotic syndrome

Long-term management of HF and HTN

30
Q

Hydrochlorothiazide (Microzide) EPA

A

Inhibits reabsorption of sodium, water, chloride and bicarbonate in the distal convoluted tubule

31
Q

Hydrochlorothiazide (Microzide) ADRs

A

electrolyte imbalances (hyponatremia, hypokalemia, hypochloremia)

hyperglycemia, hyperuricemia

32
Q

Hydrochlorothiazide (Microzide) interventions and education

A

give with food before 1500
monitor BP
daily weight
Is and Os
monitor potassium

33
Q

Hydrochlorothiazide (Microzide) contraindications and interactions

A

renal decompensation or anuria

increase lithium toxicity risk

34
Q

Spironolactone (Aldactone) class

A

Potassium Sparing Diuretic - Aldosterone Antagonist

35
Q

Spironolactone (Aldactone)
therapeutic use

A

heart failure
ascites
hypertension

36
Q

Spironolactone (Aldactone)
EPA

A

aldosterone antagonist because aldosterone has sodium retaining properties, decreases potassium excretion

37
Q

Spironolactone (Aldactone)
ADRs

A

dizziness
headache
abdomial cramping
diarrhea
hyperkalemia
androgen effects - deep voice, gynecomastia, menstrual irregularity, testicular atrophy

38
Q

Spironolactone (Aldactone)
interventions and education

A

BP, I&O, daily weight
hyperkalemia can cause heart irregularities
avoid potassium foods and salt substitutes

39
Q

Spironolactone (Aldactone)
contraindications

A

teratogenic
increased risk of hyperkalemia with ACEs and ARBs