Immune system

Question 1

cyclophosphamide class

Answer 1

alkylating agent: nitrogen mustard

Question 2

cyclophosphamide therapeutic use

Answer 2

lymphoma
leukemia
ovarian and breast cancer

Question 3

cyclophosphamide EPA

Answer 3

contains alkyl group that can kill the cell at any time in the cell cycle

Question 4

cyclophosphamide ADRs

Answer 4

alopecia
bone marrow suppression
Nausea and vomiting
kidney damage
electrolyte imbalance

Question 5

cyclophosphamide interventions and education

Answer 5

monitor I&O
give antiemetics and fluids to help kidneys
no live vaccines

Question 6

cyclophosphamide contraindications

Answer 6

pregnancy
lactation
kidney impairment

Question 7

doxorubicin class

Answer 7

anthracyclines

Question 8

doxorubicin therapeutic use

Answer 8

cancers in combination with radiation

Question 9

doxorubicin EPA

Answer 9

binds to DNA to distort it and kill cell
binds to enzyme to prevent repairing DNA

Question 10

doxorubicin ADRs

Answer 10

alopecia
cardiac toxicity
red urine and tears
liver and kidney damage

Question 11

doxorubicin interventions and education

Answer 11

central line only
cardiac toxicity can occur right away or years later
monitor for thrush
monitor liver function, CBC

Question 12

doxorubicin contraindications

Answer 12

avoid barbiturates
avoid QT prolonging drugs
pregnancy and lactation

Question 13

trastuzumab class

Answer 13

monoclonal antibodies

Question 14

trastuzumab therapeutic use

Answer 14

breast cancer

Question 15

trastuzumab EPA

Answer 15

binds to HER2 growth factor to kill cells and reducing metastasis

Question 16

trastuzumab ADRs

Answer 16

allergic reaction
flu symptoms
cardiac toxicity

Question 17

trastuzumab interventions and education

Answer 17

report rash, itchiness, SOB (allergic reaction)
report edema, SOB, insomnia, nocturia (heart failure)

Question 18

trastuzumab contraindications

Answer 18

anthracyclines
pregnancy and lactation
radiation therapy

Question 19

vincristine class

Answer 19

vinca alkaloid

Question 20

vincristine therapeutic use

Answer 20

acute leukemia
lymphoma
breast and lung cancer
Wilm’s tumor
neuroblastoma in children

Question 21

vincristine EPA

Answer 21

comes from periwinkle
disrupts M phase when mitosis occurs, kills cancer cells by disrupting division

Question 22

vincristine ADRs

Answer 22

alopecia
neuropathy
constipation

Question 23

vincristine interventions and education

Answer 23

monitor strength and feeling in hands and feet
monitor IV sites
assess bowel sounds, high fiber diet, fluids

Question 24

vincristine contraindications

Answer 24

pregnancy and lactation
charcot-marie-tooth neuro disease

Question 25

mercaptopurine (6-MP) class

Answer 25

antimetabolites: Purine Analogs

Question 26

mercaptopurine (6-MP) therapeutic use

Answer 26

acute childhood leukemia
lymphomas
autoimmune diseases

Question 27

mercaptopurine (6-MP) EPA

Answer 27

purines needed for synthesis of DNA

purine analogs block creation of purine in S phase to prevent cell division

Question 28

mercaptopurine (6-MP) ADRs

Answer 28

GI symptoms
bone marrow suppression
liver toxicity

Question 29

mercaptopurine (6-MP) interventions and education

Answer 29

decrease dose or give antiemetics for GI symtptoms
monitor CBC and liver

Question 30

mercaptopurine (6-MP) contraindications

Answer 30

pregnancy and lactation
active infection

Question 31

Delavirdine class

Answer 31

NNRTIs - non-nucleoside reverse transcriptase inhibitors

Question 32

Delavirdine therapeutic use

Answer 32

treatment of HIV

Question 33

Delavirdine EPA

Answer 33

absorbed into HIV DNA chain’s reverse transcriptase to prevent replication

Question 34

Delavirdine ADRs

Answer 34

rash, SJS
GI symptoms
elevated liver enzymes

Question 35

Delavirdine interventions and education

Answer 35

report rash
monitor weight and GI effects
monitor liver function