Infection meds Flashcards

1
Q

amoxicillin (Amoxil) class

A

penicillin

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2
Q

amoxicillin (Amoxil) therapeutic use

A

broad spectrum for gram negative bacteria, treatment of infection or prophylaxis

some gram positive for skin, soft tissue, respiratory, GI or GU infection

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3
Q

amoxicillin (Amoxil) EPA

A

inhibits bacterial cell wall synthesis, interruption of cell wall synthesis causes cell death

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4
Q

amoxicillin (Amoxil) ADRs

A

hypersensitivity
anaphylaxis
GI effects
renal and hepatic impairment
thrombophlebitis w IV administration

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5
Q

amoxicillin (Amoxil) contraindications and interactions

A

allergy to penicillin or cephalosporin
caution with severe renal impairment
safe in pregnancy and lactation

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6
Q

amoxicillin (Amoxil) interventions and education

A

monitor GI symptoms
monitor for candidiasis infection
epinephrine given for anaphylaxis
monitor BUN and creatinine

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7
Q

cefazolin (Ancef) class

A

cephalosporins

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8
Q

cefazolin (Ancef) therapeutic use

A

surgical prophylaxis

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9
Q

cefazolin (Ancef) EPA

A

inhibits bacterial wall synthesis

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10
Q

cefazolin (Ancef) interventions and education

A

monitor GI symptoms
monitor for candidiasis infection
epinephrine given for anaphylaxis
monitor BUN and creatinine

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11
Q

cefazolin (Ancef) contraindications and interactions

A

safe in pregnancy and lactation
causes bad side effects when taken with alcohol
N/V, flushing, dizziness, headache

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12
Q

aztreonam (Azactam) class

A

monobactams

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13
Q

aztreonam (Azactam) therapeutic use

A

only work on gram neg
urinary infections
lower respiratory infections
some abdominal and gyn infections

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14
Q

aztreonam (Azactam) EPA

A

inhibits bacterial wall synthesis

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15
Q

aztreonam (Azactam) ADRs

A

pain, phlebitis, and inflammation of IV
superinfection
seizures
GI effects and hypersensitivity

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16
Q

aztreonam (Azactam) contraindications and interactions

A

caution with ceph or pen allergy
not sure of safety in pregnancy and lactation

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17
Q

aztreonam (Azactam) interventions and education

A

monitor BUN and creatinine
monitor bowel function
IV form incompatible with many drugs
furosemide can increase blood levels

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18
Q

gentamicin class

A

aminoglycosides

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19
Q

gentamicin therapeutic use

A

narrow spectrum for gram neg

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20
Q

gentamicin EPA

A

disrupts protein synthesis to alter function and replication of bacteria

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21
Q

gentamicin ADRs

A

nephrotoxicity: polyuria, dilute urine, proteinuria, elevated BUN and creatinine
ototoxicity: tinnitus, headache, ataxia, vertigo
GI effects

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22
Q

gentamicin contraindications and interactions

A

avoid in pregnancy - risk for congenital deafness
avoid vanco, ceph, pen, or neuromuscular blockers
avoid in patients w tinnitus, vertigo, hearing loss

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23
Q

gentamicin interventions and education

A

monitor BUN and Creatinine
monitor serum levels
monitor for nephrotoxicity and ototoxicity
make sure patient is hydrated before starting therapy

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24
Q

ciprofloxacin (Cipro) class

A

fluoroquinolones

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25
ciprofloxacin (Cipro) therapeutic use
treats wide range of infections and treats anthrax exposure
26
ciprofloxacin (Cipro) EPA
inhibits DNA synthesis, cell growth and replication
27
ciprofloxacin (Cipro) ADRs
CNS symptoms - dizziness, headache, confusion, seizure rupture of achilles tendon
28
ciprofloxacin (Cipro) contraindications and interactions
caution in seizure disorder warfarin increases hepatotoxicity extreme caution in pregnancy and children
29
ciprofloxacin (Cipro) interventions and education
monitor for CNS symptoms monitor for Cdiff report achilles pain cover skin for sun protectionn drink 1.5L - 2L fluid per day
30
tetracycline class
tetracyclines
31
tetracycline therapeutic use
chlamydia, gonorrhea, syphilis H pylori bronchitis lyme disease
32
tetracycline EPA
inhibits protein synthesis in gram neg and pos
33
tetracycline ADRs
GI issues superinfection renal and hepatotoxicity slowed bone growth photosensitivity
34
tetracycline contraindications and interactions
mineral based products decrease absorption decrease effectiveness of oral contraceptives avoid dairy within 2 hours of taking avoid in pregnancy and children
35
tetracycline interventions and education
monitor BUN and CRE take on empty stomach report watery stools or jaundice
36
trimethoprim-sulfamethoxazole (TMP-SMZ) (Bactrim) class
sulfonamides
37
trimethoprim-sulfamethoxazole (TMP-SMZ) (Bactrim) therapeutic use
UTIs, topical for burns and wounds
38
trimethoprim-sulfamethoxazole (TMP-SMZ) (Bactrim) EPA
inhibits folic acid to stop bacterial multiplication
39
trimethoprim-sulfamethoxazole (TMP-SMZ) (Bactrim) ADRs
GI effects pancreatitis aplastic anemia, agranulocytosis, thrombocytopenia, leukopenia
40
trimethoprim-sulfamethoxazole (TMP-SMZ) (Bactrim) contraindications
newborns, lactation, pregnancy can cause hyperbilirubinemia
41
trimethoprim-sulfamethoxazole (TMP-SMZ) (Bactrim) interventions and education
monitor BUN and CRE discontinue for rash do not use with NSAIDs
42
erythromycin class
macrolides
43
erythromycin EPA
inhibits microbial protein synthesis to cause cell death
44
erythromycin ADRs
GI effects ototoxicity cardiac effects
45
erythromycin contraindications and interactions
many drug interactions caution in pregnancy and lactation caution with liver stuff
46
erythromycin interventions
monitor liver function, jaundice assess cardiac status report change in hearing, ringing in ears, or diarrhea
47
vancomycin flushing syndrome
related to rate of infusion - should be diluted and administered slowly flushing, erythema, pruritus of upper body, neck, face can also cause dyspnea and hypotension
48
Isoniazid (INH) class
antitubercular
49
Isoniazid (INH) therapeutic use
active and latent TB
50
Isoniazid (INH) EPA
Inhibits mycobacterial cell wall synthesis
51
Isoniazid (INH) ADRs
hepatotoxicity N/V peripheral neuropathy from B6 deficiency CNS effects
52
Isoniazid (INH) interventions and education
monitor liver function and symptoms avoid alcohol
53
Isoniazid (INH) contraindications
1 hour separate from antacids avoid in liver disease or alcohol abuse
54
rifampin (Rifadin) class
antitubercular rifamycin
55
rifampin (Rifadin) therapeutic use
active and latent TB leprosy meningitis
56
rifampin (Rifadin) EPA
broad spectrum antibiotic
57
rifampin (Rifadin) ADRs
turns fluids orange hepatotoxicity GI symptoms
58
rifampin (Rifadin) interventions
monitor liver function and symptoms no alcohol
59
rifampin (Rifadin) contraindications and interactions
interferes with COC avoid in liver disease and alcohol abuse
60
metronidazole (Flagyl) class
anti-parasitic azole antibiotic
61
metronidazole (Flagyl) therapeutic use
cdiff, BV, trich, giardia, abdominal infection
62
metronidazole (Flagyl) EPA
damages DNA of anaerobic bacteria
63
metronidazole (Flagyl) ADRs
GI CNS seizures and peripheral neuropathy
64
metronidazole (Flagyl) interventions and education
take with food if GI distress discontinue for seizures or neuropathy avoid alcohol darkening of urine is harmless
65
metronidazole (Flagyl) contraindications and interactions
avoid in pregnancy, blood disorders, CNS disease
66
chloroquine class
antimalarial
67
chloroquine therapeutic use
treat and prevent malaria
68
chloroquine ADRs
GI symptoms headache visual disturbances
69
chloroquine interventions and education
sunglasses can reduce visual disturbances can take with food
70
amphotericin B class
antifungal polyene antibiotic
71
amphotericin B therapeutic use
super toxic, only given with severe systemic fungal infection only administered IV
72
amphotericin B EPA
interrupt integrity of fungal cell wall
73
Nystatin
topical or PO antifungal swish and swallow for thrush
74
amphotericin B ADRs
bone marrow suppression nephrotoxicity thrombophlebitis
75
ketoconazole class
azole antifungal
76
ketoconazole therapeutic use
superficial and systemic fungal infections athletes foot, jock itch
77
ketoconazole EPA
interrupt integrity of fungal cell wall
78
ketoconazole interventions
must take PO with food for better absorption
79
acyclovir (Zovirax) class
antiviral
80
acyclovir (Zovirax) therapeutic use
HSV infection, varicella, zoster
81
acyclovir (Zovirax) EPA
inhibits replication of viral DNA
82
acyclovir (Zovirax) ADRs
renal toxicity for IV administration GI and Headache for PO CNS toxicity
82
acyclovir (Zovirax) ADRs
renal toxicity for IV administration GI and Headache for PO CNS toxicity