Infection meds Flashcards

1
Q

amoxicillin (Amoxil) class

A

penicillin

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2
Q

amoxicillin (Amoxil) therapeutic use

A

broad spectrum for gram negative bacteria, treatment of infection or prophylaxis

some gram positive for skin, soft tissue, respiratory, GI or GU infection

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3
Q

amoxicillin (Amoxil) EPA

A

inhibits bacterial cell wall synthesis, interruption of cell wall synthesis causes cell death

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4
Q

amoxicillin (Amoxil) ADRs

A

hypersensitivity
anaphylaxis
GI effects
renal and hepatic impairment
thrombophlebitis w IV administration

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5
Q

amoxicillin (Amoxil) contraindications and interactions

A

allergy to penicillin or cephalosporin
caution with severe renal impairment
safe in pregnancy and lactation

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6
Q

amoxicillin (Amoxil) interventions and education

A

monitor GI symptoms
monitor for candidiasis infection
epinephrine given for anaphylaxis
monitor BUN and creatinine

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7
Q

cefazolin (Ancef) class

A

cephalosporins

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8
Q

cefazolin (Ancef) therapeutic use

A

surgical prophylaxis

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9
Q

cefazolin (Ancef) EPA

A

inhibits bacterial wall synthesis

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10
Q

cefazolin (Ancef) interventions and education

A

monitor GI symptoms
monitor for candidiasis infection
epinephrine given for anaphylaxis
monitor BUN and creatinine

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11
Q

cefazolin (Ancef) contraindications and interactions

A

safe in pregnancy and lactation
causes bad side effects when taken with alcohol
N/V, flushing, dizziness, headache

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12
Q

aztreonam (Azactam) class

A

monobactams

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13
Q

aztreonam (Azactam) therapeutic use

A

only work on gram neg
urinary infections
lower respiratory infections
some abdominal and gyn infections

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14
Q

aztreonam (Azactam) EPA

A

inhibits bacterial wall synthesis

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15
Q

aztreonam (Azactam) ADRs

A

pain, phlebitis, and inflammation of IV
superinfection
seizures
GI effects and hypersensitivity

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16
Q

aztreonam (Azactam) contraindications and interactions

A

caution with ceph or pen allergy
not sure of safety in pregnancy and lactation

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17
Q

aztreonam (Azactam) interventions and education

A

monitor BUN and creatinine
monitor bowel function
IV form incompatible with many drugs
furosemide can increase blood levels

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18
Q

gentamicin class

A

aminoglycosides

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19
Q

gentamicin therapeutic use

A

narrow spectrum for gram neg

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20
Q

gentamicin EPA

A

disrupts protein synthesis to alter function and replication of bacteria

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21
Q

gentamicin ADRs

A

nephrotoxicity: polyuria, dilute urine, proteinuria, elevated BUN and creatinine
ototoxicity: tinnitus, headache, ataxia, vertigo
GI effects

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22
Q

gentamicin contraindications and interactions

A

avoid in pregnancy - risk for congenital deafness
avoid vanco, ceph, pen, or neuromuscular blockers
avoid in patients w tinnitus, vertigo, hearing loss

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23
Q

gentamicin interventions and education

A

monitor BUN and Creatinine
monitor serum levels
monitor for nephrotoxicity and ototoxicity
make sure patient is hydrated before starting therapy

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24
Q

ciprofloxacin (Cipro) class

A

fluoroquinolones

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25
Q

ciprofloxacin (Cipro) therapeutic use

A

treats wide range of infections and treats anthrax exposure

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26
Q

ciprofloxacin (Cipro) EPA

A

inhibits DNA synthesis, cell growth and replication

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27
Q

ciprofloxacin (Cipro) ADRs

A

CNS symptoms - dizziness, headache, confusion, seizure
rupture of achilles tendon

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28
Q

ciprofloxacin (Cipro) contraindications and interactions

A

caution in seizure disorder
warfarin increases hepatotoxicity
extreme caution in pregnancy and children

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29
Q

ciprofloxacin (Cipro) interventions and education

A

monitor for CNS symptoms
monitor for Cdiff
report achilles pain
cover skin for sun protectionn
drink 1.5L - 2L fluid per day

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30
Q

tetracycline class

A

tetracyclines

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31
Q

tetracycline therapeutic use

A

chlamydia, gonorrhea, syphilis
H pylori
bronchitis
lyme disease

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32
Q

tetracycline EPA

A

inhibits protein synthesis in gram neg and pos

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33
Q

tetracycline ADRs

A

GI issues
superinfection
renal and hepatotoxicity
slowed bone growth
photosensitivity

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34
Q

tetracycline contraindications and interactions

A

mineral based products decrease absorption
decrease effectiveness of oral contraceptives
avoid dairy within 2 hours of taking
avoid in pregnancy and children

35
Q

tetracycline interventions and education

A

monitor BUN and CRE
take on empty stomach
report watery stools or jaundice

36
Q

trimethoprim-sulfamethoxazole (TMP-SMZ) (Bactrim) class

A

sulfonamides

37
Q

trimethoprim-sulfamethoxazole (TMP-SMZ) (Bactrim) therapeutic use

A

UTIs, topical for burns and wounds

38
Q

trimethoprim-sulfamethoxazole (TMP-SMZ) (Bactrim) EPA

A

inhibits folic acid to stop bacterial multiplication

39
Q

trimethoprim-sulfamethoxazole (TMP-SMZ) (Bactrim) ADRs

A

GI effects
pancreatitis
aplastic anemia, agranulocytosis, thrombocytopenia, leukopenia

40
Q

trimethoprim-sulfamethoxazole (TMP-SMZ) (Bactrim) contraindications

A

newborns, lactation, pregnancy
can cause hyperbilirubinemia

41
Q

trimethoprim-sulfamethoxazole (TMP-SMZ) (Bactrim) interventions and education

A

monitor BUN and CRE
discontinue for rash
do not use with NSAIDs

42
Q

erythromycin class

A

macrolides

43
Q

erythromycin EPA

A

inhibits microbial protein synthesis to cause cell death

44
Q

erythromycin ADRs

A

GI effects
ototoxicity
cardiac effects

45
Q

erythromycin contraindications and interactions

A

many drug interactions
caution in pregnancy and lactation
caution with liver stuff

46
Q

erythromycin interventions

A

monitor liver function, jaundice
assess cardiac status
report change in hearing, ringing in ears, or diarrhea

47
Q

vancomycin flushing syndrome

A

related to rate of infusion - should be diluted and administered slowly

flushing, erythema, pruritus of upper body, neck, face
can also cause dyspnea and hypotension

48
Q

Isoniazid (INH) class

A

antitubercular

49
Q

Isoniazid (INH) therapeutic use

A

active and latent TB

50
Q

Isoniazid (INH) EPA

A

Inhibits mycobacterial cell wall synthesis

51
Q

Isoniazid (INH) ADRs

A

hepatotoxicity
N/V
peripheral neuropathy from B6 deficiency
CNS effects

52
Q

Isoniazid (INH) interventions and education

A

monitor liver function and symptoms
avoid alcohol

53
Q

Isoniazid (INH) contraindications

A

1 hour separate from antacids
avoid in liver disease or alcohol abuse

54
Q

rifampin (Rifadin) class

A

antitubercular rifamycin

55
Q

rifampin (Rifadin) therapeutic use

A

active and latent TB
leprosy
meningitis

56
Q

rifampin (Rifadin) EPA

A

broad spectrum antibiotic

57
Q

rifampin (Rifadin) ADRs

A

turns fluids orange
hepatotoxicity
GI symptoms

58
Q

rifampin (Rifadin) interventions

A

monitor liver function and symptoms
no alcohol

59
Q

rifampin (Rifadin) contraindications and interactions

A

interferes with COC
avoid in liver disease and alcohol abuse

60
Q

metronidazole (Flagyl) class

A

anti-parasitic azole antibiotic

61
Q

metronidazole (Flagyl) therapeutic use

A

cdiff, BV, trich, giardia, abdominal infection

62
Q

metronidazole (Flagyl) EPA

A

damages DNA of anaerobic bacteria

63
Q

metronidazole (Flagyl) ADRs

A

GI
CNS
seizures and peripheral neuropathy

64
Q

metronidazole (Flagyl) interventions and education

A

take with food if GI distress
discontinue for seizures or neuropathy
avoid alcohol
darkening of urine is harmless

65
Q

metronidazole (Flagyl) contraindications and interactions

A

avoid in pregnancy, blood disorders, CNS disease

66
Q

chloroquine class

A

antimalarial

67
Q

chloroquine therapeutic use

A

treat and prevent malaria

68
Q

chloroquine ADRs

A

GI symptoms
headache
visual disturbances

69
Q

chloroquine interventions and education

A

sunglasses can reduce visual disturbances
can take with food

70
Q

amphotericin B class

A

antifungal polyene antibiotic

71
Q

amphotericin B therapeutic use

A

super toxic, only given with severe systemic fungal infection

only administered IV

72
Q

amphotericin B EPA

A

interrupt integrity of fungal cell wall

73
Q

Nystatin

A

topical or PO antifungal

swish and swallow for thrush

74
Q

amphotericin B ADRs

A

bone marrow suppression
nephrotoxicity
thrombophlebitis

75
Q

ketoconazole class

A

azole antifungal

76
Q

ketoconazole therapeutic use

A

superficial and systemic fungal infections
athletes foot, jock itch

77
Q

ketoconazole EPA

A

interrupt integrity of fungal cell wall

78
Q

ketoconazole interventions

A

must take PO with food for better absorption

79
Q

acyclovir (Zovirax) class

A

antiviral

80
Q

acyclovir (Zovirax) therapeutic use

A

HSV infection, varicella, zoster

81
Q

acyclovir (Zovirax) EPA

A

inhibits replication of viral DNA

82
Q

acyclovir (Zovirax) ADRs

A

renal toxicity for IV administration
GI and Headache for PO
CNS toxicity

82
Q

acyclovir (Zovirax) ADRs

A

renal toxicity for IV administration
GI and Headache for PO
CNS toxicity