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Clinical Neuroscience > Pain > Flashcards

Pain Flashcards

1
Q

Acute pain

A

Does not create long term changes in nervous system and solves on its own

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2
Q

Chronic pain

A

Non-nociceptive with long term changes in nervous system (disease state)

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3
Q

What is pain?

A

Associated with actual tissue damage

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4
Q

What is nociception?

A

Stimulation of a sensory receptor signaling damage or threat of damage

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5
Q

What makes up Thermoreceptors?

A

A delta fibers and myelinated

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6
Q

What makes up mechanoreceptors?

A

A delta fibers and myelinated

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7
Q

What is a silent nociceptor?

A

Normally unresponsive but becomes responsive during inflammation after an injury

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8
Q

What percentage of cell bodies in the DRG are nociceptors?

A

75%

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9
Q

What CNS structures are apart of the pain matrix?

A

Cerebral cortices

Amygdala

Thalamus

Brainstem

Spinal cord

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10
Q

What are the anti nociceptive sites?

A

Dorsal horn

Brain stem

Hormones

Cortex

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11
Q

How does the dorsal horn contribute to anti nociception?

A

Inhibits the 2nd order nociceptor neuron in the pathway

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12
Q

How does the brainstem contribute to anti nociception?

A

Periaqueductal gray, locus coeruleus, and medulla inhibit via descending tracts to dorsal horn

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13
Q

How does the hormones contribute to anti nociception?

A

Hypothalamus, pituitary gland, and adrenal medulla inhibit nociceptor transmitters

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14
Q

How does the cortex contribute to anti nociception?

A

Amygdala impacts perception of pain using distraction and placebo

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15
Q

Hyperalgesia

A

Enhanced pain response to a normal noxious stimuli (pinch can go from 2/10 to 10/10 on injured area)

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16
Q

Secondary hyperalgesia

A

Increased pain sensitivity at an un injured site

17
Q

Allodynia

A

Nociceptors responding to non-noxious stimuli (sensation that does not usually cause pain)

(Light touch with sunburn)

18
Q

What is chronic pain associated with?

A

Maladaptive neuroplasticity

19
Q

What are some pro chronic pain factors?

A

Genetics

Stress response

Poor sleep

Mental health

20
Q

Neuropathic pain

A

Pain directly from CNS or PNS neuron structural damage

21
Q

What are examples of chronic primary pain?

A

Fibromyalgia

Chronic non-specific LBP

Complex regional pain syndrome

Migraines

22
Q

What are examples of chronic secondary pain?

A

Neuropathic pain (small fiber neuropathy and phantom pain)

Nociceptive chronic pain (arthritis, cancer, Myofascial, and pain due to traumatic injury)

Clinical Neuroscience (31 decks)

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