Paget's Disease: Pharmacologic Therapy

Question 1

Paget’s Disease: Pharmacological Management

Answer 1

1. Calcitonin
2. Bisphosphonates
3. Plicamycin (Mithracin)

Question 2

Paget’s Disease: Pharmacological Management

A polypeptide hormone

Answer 2

Calcitonin

Question 3

Paget’s Disease: Pharmacological Management

Retards bone resorption by decreasing the number and availability of osteoclasts

Answer 3

Calcitonin

Question 4

Paget’s Disease: Pharmacological Management

Produce rapid reduction in bone turnover and relief of pain

Answer 4

Bisphosphonates

Question 5

Paget’s Disease: Pharmacological Management

Bisphosphonates: examples

Answer 5

Etidronate disodium (Didronel)
Alendronate sodium (Fosamax)

Question 6

Paget’s Disease: Pharmacological Management

Cytotoxic antibiotic given IV

Answer 6

Plicamycin (Mithracin)

Question 7

Paget’s Disease: Pharmacological Management

Pain reduction and decreases serum Ca, alkaline phosphatase, and urinary hydroxyproline levels

Answer 7

Plicamycin (Mithracin)