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Hematology 1 > (P) Week 4: WBC Functions and Kinetics Part 3 > Flashcards

(P) Week 4: WBC Functions and Kinetics Part 3 Flashcards

1
Q

What does the T dependent B cell need to be activated?

A

stimuli in the form of presented antigen

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2
Q

A stimuli for T independent B cell

bacteria with lipopolysaccharide content

A

B-cell mitogen

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3
Q

__________ is also known as antigenic determinant site

A

epitope

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4
Q

Antigen known as ___________ which are
comprising of lipopolysaccharides or repetitive
epitopes or repetitive antigenic determinant sites
of a polysaccharide

A

mitogen

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5
Q

C3d and C3b are ________________ are stuck to bacteria, which stimulates the activation of the B cell

A

complement fragments

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6
Q

B cells are immunoglobulin markers and __________ which enables it to bind to either C3d or C3b (complement fragments)

A

complement receptor

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7
Q

Complimentary receptor ___ binds with C3d
Complimentary receptor ___ binds with C3b

A

II
I

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8
Q

the five different classes of immunoglobulins are differentiated through what

A

c regions

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9
Q

what type of structure is observed in immunoglobulin proteins?

A

y structure

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10
Q

Two types of immunoglobulin chains

A

heavy chain
light chain

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11
Q

antibody region where the amino acid component is constant

A

constant region

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12
Q

antibody region where it binds to different types of antigens aka “antigen-binding site”

A

variable region

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13
Q

The tail of the constant region

A

FC region / fragment

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14
Q

Two fragments of the antibody

_________ - fragment of antigen binding
__________- fragment of crystallizable fragment

A

FAB
FC

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15
Q

most effective type of antibody, lasts long in our plasma

A

IgG

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16
Q

antibody for primary immune response

A

IgM

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17
Q

antibody seen on body secretions or body fluids

A

IgA

18
Q

a process of enhancing the
phagocytic power of the phagocytes in the presence
of opsonin

A

opsonization

19
Q

The classical pathway is in the ____ line of defense, in the adaptive immunity

A

third

20
Q

T or F

The alternative and lectin pathway are part of the adaptive immunity

A

f (natural immunity)

21
Q

The classical pathway needs _______ that is bounded to a bacteria

A

antibody

22
Q

the T cytotoxic cell recognizes _______ that enters the cell

A

viruses

23
Q

In T cytotoxic cells, _____ binds with ________ to destroy virally infected cells

A

CD8+ binds with MHC type I

24
Q

produces or releases apoptotic
properties or apoptotic chemicals such as
granzyme, perforin, and granulysin

this then destroys the virus that was detected

A

CD8+

25
Q

What do NK cells recognize instead of antigens?

A

MHC molecules

26
Q

what are the two stress associated molecules

A

MICA
MICB

27
Q
  • major histocompatibility complex 1 or
    MHC type 1 sequential protein A and
    sequential protein B
A

MICA and MICB

28
Q

what are the receptors of the NK cell

A

NKG2D, NKp44, NKp46, NKp30

29
Q

________ are very effective in killing viral infected or
cancer cells. Our first line of defense against
cancer and viruses

A

NK cells

30
Q

what CD marker is needed in the antibody dependent cellular toxicity

A

CD16

31
Q

what activates the cell in the antibody dependent cellular cytotoxicity

A

Syk / tyrosine kinase

32
Q

Neutrophils and monocytes are direct descendants of
a common progenitor known as:

A

GMP

33
Q

The stage in neutrophilic development in which the
nucleus is indented in a kidney bean shape and the
cytoplasm has secondary granules that are lavender
in color is the:

A

Metamyelocyte

34
Q

Type II myeloblasts are characterized by:
a. The presence of fewer than 20 primary granules
per cell
b. Basophilic cytoplasm with many secondary
granules
c. The absence of granules

A

a

35
Q

Which one of the following is a function of neutrophils?
a. Presentation of antigen to T and B lymphocytes
b. Protection against re exposure by same antigen
c. Nonspecific destruction of foreign organisms
d. Initiation of delayed hypersensitivity response

A

c

36
Q

Which of the following cells are important in immune
regulation, allergic inflammation, and destruction of
tissue invading helminths?
a. Neutrophils and monocytes
b. Eosinophils and basophils
c. T and B lymphocytes
d. Macrophages and dendritic cells

A

b

37
Q

Basophils and mast cells have high-affinity surface
receptors for which immunoglobulin?
a. A
b. D
c. E
d. G

A

c

38
Q

Which of the following cell types is capable of
differentiating into osteoclasts, macrophages, or
dendritic cells?
a. Neutrophils
b. Lymphocytes
c. Monocytes
d. Eosinophils

A

c

39
Q

Macrophages aid in adaptive immunity by:
a. Degrading antigen and presenting it to
lymphocytes
b. Ingesting and digesting organisms that
neutrophils cannot
c. Synthesizing complement components
d. Storing iron from senescent red cells

A

a

40
Q

Which of the following is the final stage of B cell
maturation after activation by antigen?
a. Large, granular lymphocyte
b. Plasma cell
c. Reactive lymphocyte
d. Immunoblast

A

b

41
Q

The following is unique to both B and T lymphocytes
and occurs during their early development:
a. Expression of surface antigens CD4 and CD8
b. Maturation in the thymus
c. Synthesis of immunoglobulins
d. Rearrangement of antigen receptor genes

A

d

Hematology 1 (14 decks)

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