(P) Week 4: WBC Functions and Kinetics Part 3 Flashcards
What does the T dependent B cell need to be activated?
stimuli in the form of presented antigen
A stimuli for T independent B cell
bacteria with lipopolysaccharide content
B-cell mitogen
__________ is also known as antigenic determinant site
epitope
Antigen known as ___________ which are
comprising of lipopolysaccharides or repetitive
epitopes or repetitive antigenic determinant sites
of a polysaccharide
mitogen
C3d and C3b are ________________ are stuck to bacteria, which stimulates the activation of the B cell
complement fragments
B cells are immunoglobulin markers and __________ which enables it to bind to either C3d or C3b (complement fragments)
complement receptor
Complimentary receptor ___ binds with C3d
Complimentary receptor ___ binds with C3b
II
I
the five different classes of immunoglobulins are differentiated through what
c regions
what type of structure is observed in immunoglobulin proteins?
y structure
Two types of immunoglobulin chains
heavy chain
light chain
antibody region where the amino acid component is constant
constant region
antibody region where it binds to different types of antigens aka “antigen-binding site”
variable region
The tail of the constant region
FC region / fragment
Two fragments of the antibody
_________ - fragment of antigen binding
__________- fragment of crystallizable fragment
FAB
FC
most effective type of antibody, lasts long in our plasma
IgG
antibody for primary immune response
IgM
antibody seen on body secretions or body fluids
IgA
a process of enhancing the
phagocytic power of the phagocytes in the presence
of opsonin
opsonization
The classical pathway is in the ____ line of defense, in the adaptive immunity
third
T or F
The alternative and lectin pathway are part of the adaptive immunity
f (natural immunity)
The classical pathway needs _______ that is bounded to a bacteria
antibody
the T cytotoxic cell recognizes _______ that enters the cell
viruses
In T cytotoxic cells, _____ binds with ________ to destroy virally infected cells
CD8+ binds with MHC type I
produces or releases apoptotic
properties or apoptotic chemicals such as
granzyme, perforin, and granulysin
this then destroys the virus that was detected
CD8+
What do NK cells recognize instead of antigens?
MHC molecules
what are the two stress associated molecules
MICA
MICB
- major histocompatibility complex 1 or
MHC type 1 sequential protein A and
sequential protein B
MICA and MICB
what are the receptors of the NK cell
NKG2D, NKp44, NKp46, NKp30
________ are very effective in killing viral infected or
cancer cells. Our first line of defense against
cancer and viruses
NK cells
what CD marker is needed in the antibody dependent cellular toxicity
CD16
what activates the cell in the antibody dependent cellular cytotoxicity
Syk / tyrosine kinase
Neutrophils and monocytes are direct descendants of
a common progenitor known as:
GMP
The stage in neutrophilic development in which the
nucleus is indented in a kidney bean shape and the
cytoplasm has secondary granules that are lavender
in color is the:
Metamyelocyte
Type II myeloblasts are characterized by:
a. The presence of fewer than 20 primary granules
per cell
b. Basophilic cytoplasm with many secondary
granules
c. The absence of granules
a
Which one of the following is a function of neutrophils?
a. Presentation of antigen to T and B lymphocytes
b. Protection against re exposure by same antigen
c. Nonspecific destruction of foreign organisms
d. Initiation of delayed hypersensitivity response
c
Which of the following cells are important in immune
regulation, allergic inflammation, and destruction of
tissue invading helminths?
a. Neutrophils and monocytes
b. Eosinophils and basophils
c. T and B lymphocytes
d. Macrophages and dendritic cells
b
Basophils and mast cells have high-affinity surface
receptors for which immunoglobulin?
a. A
b. D
c. E
d. G
c
Which of the following cell types is capable of
differentiating into osteoclasts, macrophages, or
dendritic cells?
a. Neutrophils
b. Lymphocytes
c. Monocytes
d. Eosinophils
c
Macrophages aid in adaptive immunity by:
a. Degrading antigen and presenting it to
lymphocytes
b. Ingesting and digesting organisms that
neutrophils cannot
c. Synthesizing complement components
d. Storing iron from senescent red cells
a
Which of the following is the final stage of B cell
maturation after activation by antigen?
a. Large, granular lymphocyte
b. Plasma cell
c. Reactive lymphocyte
d. Immunoblast
b
The following is unique to both B and T lymphocytes
and occurs during their early development:
a. Expression of surface antigens CD4 and CD8
b. Maturation in the thymus
c. Synthesis of immunoglobulins
d. Rearrangement of antigen receptor genes
d
