Other places antibiotics block

Question 1

Trimethoprim/Pyrimethamine MOA? 1st Line?

Answer 1

MOA: Inhibits bacterial dihydrofolate reductase

1st Line: DOC for Shigella, Salmonella, Pneumocystis jirovecii (TMP-SMX) and prophylaxis of toxoplasmosis (pyrimethamine)

Question 2

TMP AE?

Answer 2

TMP Treats Marrow Poorly

Megaloblastic anemia, leukopenia, granulocytopenia

Question 3

Sulfonamides MOA? 1st Line?

Answer 3

MOA: Para-aminobenzoic acid (PABA) antimetabolites inhibit dihydropteroate synthase

Question 4

Sulfonamides AE?

Answer 4

1. Hypersentivity in normal patients
2. Hemolysis in G6PD def. patients
3. Kernicterus in infants

Question 5

Sulfonamides Resistance?

Answer 5

Altered enzyme

Question 6

Fluoroquinolones what do they end in?

Answer 6

-Oxacin

Question 7

Fluoroquinolones MOA?

Answer 7

MOA: Inhibit prokaryotic enzymes topoisomerase

II (DNA gyrase) and topoisomerase IV

Question 8

Prevents Introduction of negative supercoils?

Answer 8

Fluoroquinolones

Question 9

Fluoroquinolones AE?

Answer 9

Fluoroquinolones hurt attachments to your bones and heartlones

Tendonitis or tendon rupture (esp. achilles)

Torsades de points (QT interval prolongation)