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Immunology/Microbiology > Cancer Drugs > Flashcards

Cancer Drugs Flashcards

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Biology 101 flashcards
1
Q

Cladribine (2-CDA) MOA?

A

MOA: adenosine deaminase inhibitor (purine analog)

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2
Q

Cladribine Use?

A

Hairy cell leukemia

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3
Q

Cytarabine MOA?

A

Pyrimidine analog􏰀=>inhibition of DNA polymerase.

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4
Q

5 FU MOA?

A

Pyrimidine analog=>inhibits thymidylate synthase

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5
Q

Is there an antidote for 5 FU?

A

No

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6
Q

MTX MOA?

A

Folic acid analog=> inhibits dihydrofolate reductase

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7
Q

Topical 5 FU used for?

A

Basal Cell carcinoma

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8
Q

MTX AE? Tx?

A

Pulm. fibrosis

Myelosuppression=>use leucovorin rescue

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9
Q

Bleomycin MOA?

A

Induces free radical formation=> 􏰀breaks in DNA strands.

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10
Q

Dactinomycin (actinomycin D) MOA?

A

Intercalates DNA

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11
Q

Dactinomycin (actinomycin D) use?

A

Children Act Out

Wilms Tumor, Ewing Sarcoma

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12
Q

Doxorubicin, daunorubicin MOA?

A

Free radicals and intercalates

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13
Q

Doxorubicin, daunorubicin AE? Tx?

A

Cardiotoxicity (dilated cardiomyopathy)

Tx: Dexrazoxane

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14
Q

Busulfan MOA?

A

Cross-links DNA

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15
Q

Busulfan Use?

A

CML

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16
Q

Cyclophosphamide, ifosfamide MOA? Requires activation by?

A

Cross-link DNA at guanine N-7.

Liver

17
Q

Cyclophosphamide AE? Tx?

A

hemorrhagic cystitis; Mensa

18
Q

Nitrosoureas (carmustine, lomustine, semustine, streptozocin)

Mustard Gas!

A

Cross-link DNA and crosses CNS=>good for brain tumors

19
Q

Pay Taxes to?

A

Stabilize (Paciltaxel)

20
Q

Vincristine vs Vinblastine AE?

A

Chris Christine gives me the tingles (neurotoxicity)

21
Q

Cisplatin another name?

A

Cisbladder?

22
Q

Cisplatin AE? Tx?

A

Nephrotoxicity; Amifostine

23
Q

ETOPOside, teniposide MOA?

A

Etoposide inhibits topoisomerase II􏰀􏰃=> increased DNA degradation.

24
Q

Irinotecan, topotecan

A

Inhibit topoisomerase I and prevent DNA unwinding and replication.

25
Q

Hydroxyurea increases?

A

HbF

26
Q

Bleomycin acts on phase?

A

G2

27
Q

Paclitaxel, Vinblastine, Vincristine all act on?

A

M phase

28
Q

Carmustine, Cisplatin and lomustine all act on?

A

Go

29
Q

Etoposide/Teniposide act on?

A

G2 and S

Immunology/Microbiology (32 decks)

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