Cancer Drugs Flashcards
Cladribine (2-CDA) MOA?
MOA: adenosine deaminase inhibitor (purine analog)
Cladribine Use?
Hairy cell leukemia
Cytarabine MOA?
Pyrimidine analog=>inhibition of DNA polymerase.
5 FU MOA?
Pyrimidine analog=>inhibits thymidylate synthase
Is there an antidote for 5 FU?
No
MTX MOA?
Folic acid analog=> inhibits dihydrofolate reductase
Topical 5 FU used for?
Basal Cell carcinoma
MTX AE? Tx?
Pulm. fibrosis
Myelosuppression=>use leucovorin rescue
Bleomycin MOA?
Induces free radical formation=> breaks in DNA strands.
Dactinomycin (actinomycin D) MOA?
Intercalates DNA
Dactinomycin (actinomycin D) use?
Children Act Out
Wilms Tumor, Ewing Sarcoma
Doxorubicin, daunorubicin MOA?
Free radicals and intercalates
Doxorubicin, daunorubicin AE? Tx?
Cardiotoxicity (dilated cardiomyopathy)
Tx: Dexrazoxane
Busulfan MOA?
Cross-links DNA
Busulfan Use?
CML
Cyclophosphamide, ifosfamide MOA? Requires activation by?
Cross-link DNA at guanine N-7.
Liver
Cyclophosphamide AE? Tx?
hemorrhagic cystitis; Mensa
Nitrosoureas (carmustine, lomustine, semustine, streptozocin)
Mustard Gas!
Cross-link DNA and crosses CNS=>good for brain tumors
Pay Taxes to?
Stabilize (Paciltaxel)
Vincristine vs Vinblastine AE?
Chris Christine gives me the tingles (neurotoxicity)
Cisplatin another name?
Cisbladder?
Cisplatin AE? Tx?
Nephrotoxicity; Amifostine
ETOPOside, teniposide MOA?
Etoposide inhibits topoisomerase II=> increased DNA degradation.
Irinotecan, topotecan
Inhibit topoisomerase I and prevent DNA unwinding and replication.
