Immunopharmacology

Question 1

Glucocorticoids MOA?

Answer 1

MOA: Inhibit NF-κB. Suppress both B- and

T-cell function by decreased 􏰂transcription of many cytokines.

Question 2

Azathioprine MOA? Activated by?

Answer 2

MOA: Inhibits lymphocyte proliferation by blocking nucleotide synthesis.

Activated by HGPRT

Question 3

Azathioprine AE?

Answer 3

Bone marrow suppression

Question 4

Azathioprine DDI?

Answer 4

6-MP degraded by xanthine oxidase;

toxicity 􏰁Increased by allopurinol and febuxostat.

Question 5

Daclizumab, basiliximab MOA?

Answer 5

MOA: Monoclonal antibodies; block IL-2R

Question 6

Sirolimus (Rapamycin) MOA?

Answer 6

MOA: binds FKBP=>mTOR inhibitor=>preventing response to IL-2.

Question 7

Does the Kidney Sir-Vive?

Answer 7

Yes

Question 8

Tacrolimus (FK506) MOA?

Answer 8

MOA: binds FK506 binding protein (FKBP)=>Calcineurin inhibitor=>preventing response to IL-2.

Question 9

Cyclosporine MOA?

Answer 9

MOA: binds cyclophilin=>Calcineurin inhibitor=>preventing response to IL-2

Question 10

Both Cyclosporine and Tacrolimus have what AE?

Answer 10

Nephrotoxicity, Neurotoxicity

Question 11

Difference between Cyclosporine and Tacrolimus?

Answer 11

Cyclosporine has gingival hyperplasia