Apoptosis/Necrosis+ Cellular Injury

Question 1

Apoptosis vs Necrosis?

Answer 1

Apoptosis=Suicide

Necrosis=Murder

Question 2

Does Apoptosis require ATP?

Answer 2

Yes

Question 3

Which cell death, Apoptosis vs Necrosis has inflammation?

Answer 3

Necrosis

Question 4

Name the characteristics of Apoptosis

Answer 4

Cell shrinkage, nuclear shrinkage (pyknosis) membrane blebbing, nuclear fragmentation (karyorrhexis), and formation of apoptotic
bodies

Question 5

apoptotic bodies are phagocytosed by?

Answer 5

Marcophages

Question 6

Apoptosis means?

Answer 6

Falling into pieces

Question 7

What is it when fragments in multiples of 180 bp are found in the cell? What is it an indication of?

Answer 7

DNA laddering

Apoptosis

Question 8

How does radiation therapy kill cells?

Answer 8

Free Radical and dsDNA breakage

Question 9

Which cells are very susceptible to radiation therapy?

Answer 9

Skin and GI

Question 10

Give 3 examples of apoptosis?

Answer 10

1. Endometrium shedding
2. Removal of cells during embryogenesis
3. CD8 cells killing virally infected cells

Question 11

All neutrophils after resolution undergo?

Answer 11

Apoptosis

Question 12

Decreased IL-2 can lead to apoptosis via the ?

Answer 12

Intrinsic pathway

Question 13

Decreased survival signal and DNA damage blocks?

Answer 13

Bcl-2=>BAX=>Cytochrome c=>caspases=>activated

Question 14

Bcl2 specifically inhibits?

Answer 14

Apaf-1

Question 15

If Bcl-2 is overly expressed, what tumor do you get?

Answer 15

Follicular Lymphoma

Question 16

Extrinsic pathway’s FAS ligand is found in what place in the body?

Answer 16

Medullary negative selection

Question 17

Defective Fas-FasL interactions contribute to?

Answer 17

autoimmune disorders

Question 18

FAS links with FASL and creates?

Answer 18

FADD=>caspases

Question 19

Necrosis is always followed by?

Answer 19

Inflammation

Question 20

Coagulative necrosis is seen in?

Answer 20

Ischemia/infarcts in most tissues (except brain)

Question 21

In coagulative are the cell outlines preserved?

Answer 21

Yes

Question 22

What kind of an infarction do you get in Coagulative necrosis?

Answer 22

Wedge-shaped and pale

Question 23

Liquefactive necrosis is seen in three places where are they?

Answer 23

Brain, Pancreatitis (parenchyma) and Bacterial abscesses

Question 24

Liquefactive necrosis is due to?

Answer 24

Enzyme degradation

Question 25

What liquifies the brain?

Answer 25

Microglial cells

Question 26

What creates an abscess?

Answer 26

Neutrophils via lysosomes

Question 27

Caseous Necrosis is from?

Answer 27

TB and Histo

Question 28

Fat Necrosis leads to?

Answer 28

Saponification

Question 29

What is saponification?

Answer 29

Ca2+ +fat=>white chalky appearance

Appear blue in H&E

Question 30

Fat Necrosis is seen in two tissues?

Answer 30

Enzymatic fat necrosis in pancreatitis

Noneznymatic fat necrosis of breast

Question 31

Fibrinoid Necrosis is seen in two places?

Answer 31

1. Malignant HTN

2. Vasculitis

Question 32

30 y/o woman w/ preeclampsia will have what kind of necrosis?

Answer 32

Fibrinoid

Question 33

Ischemia of the lower limb?

Answer 33

Gangrenous (mummified)

Question 34

Add infection to dry gangren?

Answer 34

Wet