Acute Inflammation Flashcards
3 ways mast cells get activated?
- Tissue Trauma
- C5a
- Cross-Linking of cell surface IgE by antigen
1st phase reaction is Histamine what does it do?
- vasodilation of arterioles
2. vasopermeability at the level of post capillary venule
2nd phase reaction is Leukotrienes via AA what does it do?
Delayed response/sustained response
4 Key chemotactic agents?
- LTB4
- C5a
- IL-8
- Bacterial prodcut
Pain is mediated by? How?
PGE2 and Bradykinin=>sensitize the sensory nerve endings
Vasodilation (Redness/Rubor) is mediated by?
histamine* (primary), PGs and bradykinin
Vasopermeability/Leakage for swelling occurs in the?
Postcapillary venule
How does Fever Occur? Start with pyrogens
Pyrogens=>macrophage=>IL-1 and TNF=>hit perivascular cells of hypothalamus and increase COX activity=>increased PGE2 raises temperature set point.
Where do the neutrophils come in during margination?
Postcapillary venule
Neutrophils hit speed bumps during rolling, what are they and where do they come from?
P-selectin from WP bodies
E-Selectin from TNF and IL-1
What are the leukocyte particles that the speed bumps hit?
Sialyl-LewisX
Cells Tightly bind to the cell by? Regulated by?
Cellular Adhesion (CAMS); TNF and IL-1
What do these CAMs bind to? What stimulates it?
Integrin on the cell (think of those that are chemotactic agents)
Necrosis leads to?
Acute inflammation
Macrophages kill cells by O2 independent mechanisms like?
Lysosomes
