Carcinogens

Question 1

Alfatoxins (Aspergillus)

Answer 1

Hepatocellular Carcinoma

Question 2

Alkylating agents

Answer 2

Leukemia/lymphoma

Question 3

Aromatic amines (e.g., benzidine, 2-naphthylamine)

Answer 3

Transitional cell carcinoma

Question 4

Alcohol and Cigarette Smoke

Answer 4

Squamous Cell Carcinoma of the Oropharynx and Upper Esophagus

Question 5

Arsenic

Answer 5

Squamous cell carcinoma of Skin

Lung Cancer

Question 6

Asbestos (Super High Yield)

Answer 6

**Bronchogenic carcinoma > mesothelioma

Question 7

MC carcinogen?

Answer 7

Smoking

Question 8

Most Important carcinogen in smoke?

Answer 8

polycyclic hydrocarbons

Question 9

Bladder and smoking?

Answer 9

Urothelial and Kidney Cancer

Napthylene

Question 10

Nitrosamines (smoked foods)

Answer 10

Gastric Cancer (intestinal type)

Question 11

Vinyl chloride=>PVC (high yield)

Answer 11

Angiosarcoma

Question 12

EBV (Super High Yield)

Answer 12

Burkitt lymphoma

Hodgkin lymphoma

Nasopharyngeal carcinoma (neck mass in chinese male and african person),

1° CNS lymphoma (in immunocompromised patients)

Question 13

HHV-8

Answer 13

Kaposi sarcoma

1. Older Eastern European Males
2. AIDS patient
3. Transplant

Question 14

HTLV-1

Answer 14

Adult T-cell leukemia/lymphoma

Question 15

Ionizing radiation, MOA?

Answer 15

Papillary thyroid carcinoma, AML and CML

MOA: Hydroxyl Free Radicals

Question 16

Non ionizing=>UVB (MC)

Answer 16

BCC
SCC
Melanoma
MOA: Pyrimidine dimers (No endonucleases in xerothoma pigmentosa)