Autoantibodies Flashcards

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1
Q

Anti-Ach receptor

A

Myasthenia gravis

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2
Q

Anti-basement membrane

A

Goodpasture syndrome

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3
Q

Anticardiolipin, lupus anticoagulant

A

SLE, Antiphospholipid syndrome

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4
Q

Anticentromere

A

Limited scleroderma (CREST syndrome)

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5
Q

Anti-desmosome (anti-desmoglein)

A

Pemphigus vulgaris

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6
Q

Anti-dsDNA, anti-Smith

A

SLE

dsDNA=>Damaged Nephrons

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7
Q

Anti-glutamic acid decarboxylase (GAD-65)

A

Type 1 DM

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8
Q

Antihemidesmosome

A

Bullous pemphigoid

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9
Q

Anti-histone

A

Drug-induced Lupus

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10
Q

Anti-Jo-1, anti-SRP, anti-Mi-2

A

Polymyositis, dermatomyositis

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11
Q

Antimicrosomal, antithyroglobulin

A

Hashimoto thyroiditis

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12
Q

Anti-mitochondrial

A

Primary Biliary Cirrhosis

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13
Q

Anti-nuclear antibodies

A

SLE, Nonspecific

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14
Q

Anti-parietal cell

A

Pernicious anemia

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15
Q

Anti-Scl-70 (anti-DNA topoisomerase)

A

Scleroderma (Diffuse)

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16
Q

Anti-smooth muscle

A

Autoimmune hepatitis

17
Q

Anti-SSA, Anti-SSB (Anti-Ro, Anti-La)

A

Sjorgen Syndrome

18
Q

Anti-TSH receptor

A

Graves Disease

19
Q

Anti-U1 RNP

A

Mixed connective tissue disease

20
Q

IgA anti-endomysial, IgA anti-tissue transglutaminase

A

Celiac Disease

21
Q

MPO-ANCA/p-ANCA

A

Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

22
Q

PR3-ANCA/c-ANCA

A

WeCener’s granulomatosis (granulomatosis with polyangiitis)

23
Q

Rheumatoid Factor(IgM Ab against IgG Fc Region) *non specific, anti-CCP (more specific)

A

Rheumatoid arthritis