oral environment & dry mouth Flashcards
1
Q
what are microbial independent factors (allogenic)
A
- tooth eruption
- restorations, implants, veneers, braces
- dentures
- saliva components
- salivary gland dysfunction, sjorgens, radiation therapy
- antimicrobial agents, toothpaste, mouthwash, prescription
- immunity; disease (diabetes), infection (HIV) drugs (inhalers-steroids)
2
Q
what are microbial dependent factors (autogenic)
A
- oxygen consumption
- food chains
- adhesion molecules
- bacteriocins
3
Q
what are microbial interactions of saliva?
A
- adherence
- degraded to reveal binding site
- degraded to provide nutrition
- bind bacteria for mucocilliary clearance
- degraded to release antibacterial peptides
4
Q
what are the bacterial interactions of MG1 (MUC5B)?
A
- attracts some species S.sanguinis, S.mitis & Actinomyces spp
- associated with soluble phase, and rapid flushing out of material
5
Q
describe statherin
A
- N-terminus prevents both primary & secondary Calcium Phosphate disposition
- Aids A.viscosus & F.nucleatum binding to HA
- C-terminal involved only upon binding to pellicle & conformational change
- inhibits hypha formation by candida species
6
Q
describe cystatins
A
- inhibitors of cysteine proteases
- include unique cystatins restricted to oral environment
- Cystatin SA linked with pellicle formation & remineralisation
- may function in control of periodontal disease
- protect other salivary proteins from degradation
7
Q
describe HOSCN
A
- low pH favours HOSCN
- Due to uncharged nature, HOSCN penetrates bacterial cell envelope better than OSCN-
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