When does phosphorylation only occur?

On serine, Threonine and Tyrosine residue reversible

Growth factors in OSCC

Epidermal growth factor (EGF) and Transforming growth factor alpha (TGF-α) (most common) ➢ Promotes cell proliferation in oral tissues ➢ Overexpressed in oral carcinogenesis ➢ Overexpressed in 80-90% OSCC ➢ Stimulates target cell by binding to the epidermal growth factor receptor (EGFR) ➢ EGFR protein is overexpressed in 40-50% HNSCC ➢ Salivary EGF- Oral tissue integrity

VEGF (vascular endothelial growth factor)

➢ Plays important role in angiogenesis ➢ Angiogenesis is indispensable for the proliferation and metastasis of solid tumours, including head and neck squamous cell carcinoma. ➢ Binds with VEGF receptor 1,2, and 3 ➢ The percentage of VEGF-positive OSCC cases differs from 25% to 100% with mean positivity of 78% ➢ Several studies have shown that overexpression of VEGF is associated with worse survival

Cell signalling pathways Flashcards by Cameron Pollock

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Cell signalling pathways Flashcards

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