Oncology Flashcards
1
Q
RAS
A
- proto-oncogene
- GTP-binding protein in MAP-kinase signal transduction system
2
Q
MYC
A
- proto-onc
- transcription factor
3
Q
ERBB1/EGFR
A
- proto-onc
- receptor tyrosine kinase
4
Q
ERBB2/HER2
A
- proto-onc
- receptor tyrosine kinase
5
Q
ABL
A
- proto-onc
- nonreceptor tyrosine kinase
6
Q
BRAF
A
- proto-onc
- Ras signal transduction
7
Q
BRCA1/2
A
- TS
- DNA repair
8
Q
APC/B-catenin
A
- TS
- Wnt signaling pathway
9
Q
p53
A
- TS
- genomic stability
10
Q
RB
A
- TS
- G1/S transition inhibitor
11
Q
WT1
A
- TS
- urogenital differentiation
12
Q
VHL
A
- TS
- Ubiquitin ligase component
13
Q
RAS cancers
A
- cholangiocarcinoma
- pancreatic adenocarcinoma
14
Q
MYC cancers
A
Burkitt lymphoma
15
Q
EGFR cancers
A
lung adenocarcinoma
16
Q
HER2 cancers
A
breast
17
Q
ABL cancers
A
chronic myelogenous leukemia
18
Q
BRAF cancers
A
- hairy cell leukemia
- melanoma
19
Q
BRCA1/2 cancers
A
- breast & ovarian
20
Q
APC/B-catenin cancers
A
- colon, gastric & pancreatic cancer
- FAP
21
Q
p53 cancers
A
- most cancers
- Li-Fraumeni syndrome
22
Q
RB cancers
A
- retinoblastoma
- osteosarcoma
23
Q
WT1 cancers
A
- Wilms tumor
24
Q
VHL cancers
A
- Renal cell carcinoma
- Von Hippel-Lindau syndrome (hemangiomas)
