Oncology Flashcards

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1
Q

RAS

A
  • proto-oncogene

- GTP-binding protein in MAP-kinase signal transduction system

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2
Q

MYC

A
  • proto-onc

- transcription factor

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3
Q

ERBB1/EGFR

A
  • proto-onc

- receptor tyrosine kinase

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4
Q

ERBB2/HER2

A
  • proto-onc

- receptor tyrosine kinase

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5
Q

ABL

A
  • proto-onc

- nonreceptor tyrosine kinase

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6
Q

BRAF

A
  • proto-onc

- Ras signal transduction

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7
Q

BRCA1/2

A
  • TS

- DNA repair

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8
Q

APC/B-catenin

A
  • TS

- Wnt signaling pathway

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9
Q

p53

A
  • TS

- genomic stability

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10
Q

RB

A
  • TS

- G1/S transition inhibitor

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11
Q

WT1

A
  • TS

- urogenital differentiation

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12
Q

VHL

A
  • TS

- Ubiquitin ligase component

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13
Q

RAS cancers

A
  • cholangiocarcinoma

- pancreatic adenocarcinoma

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14
Q

MYC cancers

A

Burkitt lymphoma

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15
Q

EGFR cancers

A

lung adenocarcinoma

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16
Q

HER2 cancers

A

breast

17
Q

ABL cancers

A

chronic myelogenous leukemia

18
Q

BRAF cancers

A
  • hairy cell leukemia

- melanoma

19
Q

BRCA1/2 cancers

A
  • breast & ovarian
20
Q

APC/B-catenin cancers

A
  • colon, gastric & pancreatic cancer

- FAP

21
Q

p53 cancers

A
  • most cancers

- Li-Fraumeni syndrome

22
Q

RB cancers

A
  • retinoblastoma

- osteosarcoma

23
Q

WT1 cancers

A
  • Wilms tumor
24
Q

VHL cancers

A
  • Renal cell carcinoma

- Von Hippel-Lindau syndrome (hemangiomas)