-mabs Flashcards
1
Q
Alemtuzumab
A
CD52
2
Q
Bevacizumab
A
BEGF
3
Q
Cetuximab
A
EGFR
4
Q
Rituximab
A
CD20
5
Q
Trastuzumab
A
HER2/neu
6
Q
Topoisomerase inhib phase
A
S and G2
7
Q
Antimetabolite phase
A
S
8
Q
Cell cycle-indep drugs
A
Platinum
Alkylating
9
Q
MT inhibitors
A
M
10
Q
What is minoxidil used for?
A
alopecia (art vasodil)
11
Q
What is tamsulosin?
A
alpha 1 antag for BPH
12
Q
What is danazol?
A
partial agonist at androgen receptors (used for endometriosis and hereditary angioedema)
13
Q
Name me some aromatase inhibitors
A
Anastrozole, letrozole, exemestane
14
Q
Adalimumab
A
TNF-alpha
15
Q
Certolizumab
A
TNF-alpha
16
Q
Infliximab
A
TNF-alpha
17
Q
Eculizumab
A
Complement C5 (for Paroxysmal nocturnal hemoglobinuria)
18
Q
Natalizumab
A
alpha4-integrin (for MS and Crohn’s)
19
Q
Abciximab
A
Plt IIb/IIIa
20
Q
Denosumab
A
RANKL
21
Q
Palivizumab
A
RSV F protein
22
Q
Ranibizumab
A
VEGF
23
Q
Bevacizumab
A
VEGF
24
Q
Omalizumab
A
IgE (for asthma)
25
Basiliximab
IL-2R
26
Daclizumab
IL-2R
27
Cyclosporine
Calcineurin inhib (cyclophilin) inhibits NFAT TF to activate
28
Tacrolimus
Calcineurin inhib (FKBP) inhibit NFAT TF to activate
29
Aldesleukin
IL-2 analog (for RCC and melanoma)
30
Romiplostim, eltrombopag
Thrombopoitein agonist
31
Oprelvekin
IL-11 for thrombocytopenia
32
Sirolilmus (rapamycin)
mTOF inhibitor (from IL-2R)
33
Mycopenholate
inhib IMP dehydrogenase
34
Azathioprine
becomes 6-MP to inhibit PRPP amidotransferase to decrease purine synth
35
Corticosteroids
inhibit NF-KB and inflammatory cytokine genes (inhib phospholipase 2 to reduce AA metab)
