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Step 1 - USMLE Factoids > -mabs > Flashcards

-mabs Flashcards

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USMLE® Step 1 flashcards
1
Q

Alemtuzumab

A

CD52

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2
Q

Bevacizumab

A

BEGF

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3
Q

Cetuximab

A

EGFR

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4
Q

Rituximab

A

CD20

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5
Q

Trastuzumab

A

HER2/neu

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6
Q

Topoisomerase inhib phase

A

S and G2

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7
Q

Antimetabolite phase

A

S

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8
Q

Cell cycle-indep drugs

A

Platinum

Alkylating

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9
Q

MT inhibitors

A

M

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10
Q

What is minoxidil used for?

A

alopecia (art vasodil)

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11
Q

What is tamsulosin?

A

alpha 1 antag for BPH

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12
Q

What is danazol?

A

partial agonist at androgen receptors (used for endometriosis and hereditary angioedema)

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13
Q

Name me some aromatase inhibitors

A

Anastrozole, letrozole, exemestane

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14
Q

Adalimumab

A

TNF-alpha

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15
Q

Certolizumab

A

TNF-alpha

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16
Q

Infliximab

A

TNF-alpha

17
Q

Eculizumab

A

Complement C5 (for Paroxysmal nocturnal hemoglobinuria)

18
Q

Natalizumab

A

alpha4-integrin (for MS and Crohn’s)

19
Q

Abciximab

A

Plt IIb/IIIa

20
Q

Denosumab

A

RANKL

21
Q

Palivizumab

A

RSV F protein

22
Q

Ranibizumab

A

VEGF

23
Q

Bevacizumab

A

VEGF

24
Q

Omalizumab

A

IgE (for asthma)

25
Q

Basiliximab

A

IL-2R

26
Q

Daclizumab

A

IL-2R

27
Q

Cyclosporine

A

Calcineurin inhib (cyclophilin) inhibits NFAT TF to activate

28
Q

Tacrolimus

A

Calcineurin inhib (FKBP) inhibit NFAT TF to activate

29
Q

Aldesleukin

A

IL-2 analog (for RCC and melanoma)

30
Q

Romiplostim, eltrombopag

A

Thrombopoitein agonist

31
Q

Oprelvekin

A

IL-11 for thrombocytopenia

32
Q

Sirolilmus (rapamycin)

A

mTOF inhibitor (from IL-2R)

33
Q

Mycopenholate

A

inhib IMP dehydrogenase

34
Q

Azathioprine

A

becomes 6-MP to inhibit PRPP amidotransferase to decrease purine synth

35
Q

Corticosteroids

A

inhibit NF-KB and inflammatory cytokine genes (inhib phospholipase 2 to reduce AA metab)

Step 1 - USMLE Factoids (37 decks)

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