CV Physiology Flashcards

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1
Q

Equation for cardiac output

A

Cardiac Output = stroke volume * heart rate

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2
Q

Mean arterial pressure (MAP) equation

A

MAP = cardiac output * total peripheral resistance

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3
Q

Pulse pressure equation

A

PP = systolic pressure - diastolic pressure

(therefore you’d get LESS pulse pressure in anything that increases compliance (like sepsis) and decreases stroke volume (like heart failure))

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4
Q

Does DECREASED extracellular Na+ increase or decrease contractility?

A

Increase (because less Na+ OUT means that the Na+/Ca+2 pump will work LESS, and thus less Ca+2 will be pumped out)

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5
Q

Which way does the cardiac Na+/Ca+2 usually go?

A

Na+ IN

Ca+2 OUT

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6
Q

Preload depends on _________ tone.

A

Venous (thus vEnodilators decrease prEload)

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7
Q

How does the heart compensate for long-standing HTN?

A

Concentric left ventricular hypertrophy

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8
Q

What is the measurable difference between systolic and diastolic HF (not symptoms)?

A

ejection fraction

EF decreases in SYSTOLIC HF whereas normal in diastolic HF

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9
Q

What is normal EF?

A

55%

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10
Q

Ohm’s law for the heart

A

change in pressure = flow * resistance

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11
Q

___________ have the highest toal cross-sectional area and lowest flow velocity.

A

Capillaries

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12
Q

_____________ depends mostly on hematocrit but can increase in hyperproteinemic states.

A

Viscosity

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13
Q

What accounts for most of the total peripheral resistance?

A

arterioles (they still have muscle of them!)

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14
Q

What provides most of the blood storage capacity?

A

Veins

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15
Q

Pressures in all four heart chambers, aorta, and pulm artery.

A
RA: <5
RV: 25/5
Pulm artery: 25/10
LA: <10
LV: 120/10
Aorta: 120/80
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16
Q

What is the equation for volumetric flow rate (Q)

A

Q = flow velocity * cross-sectional area

17
Q

Phase 0 in myocytes vs pacemakers

A

Myocytes: Na+ in

Pacemakers: Ca+2 in

18
Q

Heart rate is determined by:

A

phase 4 (I-funny current from Na+ and K+ influx)

19
Q

ANP and BNP mech of action

A
  • released from increase blood vol/pressure/tension
  • acts via cGMP

Causes:

  • vasodil
  • decreases Na+ reabs at CT
  • dilates afferent renal arteriole and constricts efferent arterioles to promote diuresis (aldo escape)
20
Q

ANP vs. BNP differences

A

ANP: released by atrial myocytes and causes “aldosterone escape”

BNP: released by ventricular myocytes, longer 1/2 life, used to diagnose and treat HF