Immunology

Question 1

Lymph node: follicle

Answer 1

B cells

Question 2

Lymph node: paracortex

Answer 2

T cells (therefore, not devo in DiGeorge)

Question 3

Ovaries and testes drain to which lymph node?

Answer 3

Para-aortic because they start high and migrate down

Question 4

What does the RIGHT lymphatic duct drain?

Answer 4

Right side of body ABOVE diaphragm

Question 5

What does the thoracic duct drain

Answer 5

EVERYWHERE except the right side above the diaphragm

Question 6

Encapsulated organisms: Please SHINE my SKiS

Answer 6

Pseudo a.

Strep pneumo
H. influenzae (type B)
Neisseria
E. coli

Salmonella
Klebsiella
(i)
Strep (Group B)

Question 7

Signs of splenectomy in an RBC smear

Answer 7

• Howell Jolly bodies

- Target cells

Question 8

Where do T cells develop?

Answer 8

Thymus

Question 9

Where do B cells develop?

Answer 9

Bone marrow

Question 10

Which congenital immunodeficiency diseases lack a thymus?

Answer 10

SCID
DiGeorge
(larger in myasthenia gravis)

Question 11

Thymus is derived from the _____ pharyngeal pouch.

Answer 11

THird (for THymus)

Question 12

Cells in innate immunity

Answer 12

PMNs, macs, NK cells, dendritic cells, complement

Question 13

Cells in adaptive immunity

Answer 13

B cells (and their Abs), T cells

Question 14

Pathogen recognition in innate immunity

Answer 14

Toll-like receptors (TLRs)

Question 15

Pathogen recognition in adaptive immunity

Answer 15

Memory cells (lead to quicker, stronger response at 2nd exposure)

Question 16

Which type of immunity (innate or adaptive) uses V(D)J recombination?

Answer 16

Adaptive

Question 17

What are TLRs?

Answer 17

Pattern recognition receptors that identify PAMPs (pathogen-associated molecular patterns)

Question 18

What are some examples of PAMPs?

Answer 18

• LPS from G- bacteria
• flagellin from bacteria
• nucleic acids from viruses

Question 19

How do you recognize an HLA I vs II loci from their name?

Answer 19

HLA I loci have 1 letter (HLA-A, B, C)

HLA II loci have 2 letters (HLA DQ, DR, etc)

Question 20

HLA I is read by ___________ immune cells whereas HLA II is read by _____________ immune cells.

Answer 20

HLA I = CD8
HLA II = CD4

(Rule of 8: 18=8 and 24=8)

Question 21

What do HLA I present?

Answer 21

ENDOGENOUS Ag to CD8 (good for viruses)

Question 22

What do HLA II present

Answer 22

EXOGENOUS Ag to CD4

Question 23

In the cell, where are Ag loaded onto MHC I?

Answer 23

RER

Question 24

MHC I is expressed by ___________.

Answer 24

All cells with a nucleus (NOT RBCs)

Question 25

MHC II is expressed by ____________.

Answer 25

APCs

Question 26

What type of immune cell is responsible for Type IV delayed hypersensitivity?

Answer 26

CD8