Immunology Flashcards
Lymph node: follicle
B cells
Lymph node: paracortex
T cells (therefore, not devo in DiGeorge)
Ovaries and testes drain to which lymph node?
Para-aortic because they start high and migrate down
What does the RIGHT lymphatic duct drain?
Right side of body ABOVE diaphragm
What does the thoracic duct drain
EVERYWHERE except the right side above the diaphragm
Encapsulated organisms: Please SHINE my SKiS
Pseudo a.
Strep pneumo
H. influenzae (type B)
Neisseria
E. coli
Salmonella
Klebsiella
(i)
Strep (Group B)
Signs of splenectomy in an RBC smear
- Howell Jolly bodies
- Target cells
Where do T cells develop?
Thymus
Where do B cells develop?
Bone marrow
Which congenital immunodeficiency diseases lack a thymus?
SCID
DiGeorge
(larger in myasthenia gravis)
Thymus is derived from the _____ pharyngeal pouch.
THird (for THymus)
Cells in innate immunity
PMNs, macs, NK cells, dendritic cells, complement
Cells in adaptive immunity
B cells (and their Abs), T cells
Pathogen recognition in innate immunity
Toll-like receptors (TLRs)
Pathogen recognition in adaptive immunity
Memory cells (lead to quicker, stronger response at 2nd exposure)
Which type of immunity (innate or adaptive) uses V(D)J recombination?
Adaptive
What are TLRs?
Pattern recognition receptors that identify PAMPs (pathogen-associated molecular patterns)
What are some examples of PAMPs?
- LPS from G- bacteria
- flagellin from bacteria
- nucleic acids from viruses
How do you recognize an HLA I vs II loci from their name?
HLA I loci have 1 letter (HLA-A, B, C)
HLA II loci have 2 letters (HLA DQ, DR, etc)
HLA I is read by ___________ immune cells whereas HLA II is read by _____________ immune cells.
HLA I = CD8
HLA II = CD4
(Rule of 8: 18=8 and 24=8)
What do HLA I present?
ENDOGENOUS Ag to CD8 (good for viruses)
What do HLA II present
EXOGENOUS Ag to CD4
In the cell, where are Ag loaded onto MHC I?
RER
MHC I is expressed by ___________.
All cells with a nucleus (NOT RBCs)
MHC II is expressed by ____________.
APCs
What type of immune cell is responsible for Type IV delayed hypersensitivity?
CD8
