HLAs and Trinucleotide expansions

Question 1

HLA A3

Answer 1

Hemochromatosis

Question 2

HLA B8 (BB8)

Answer 2

Addison disease
Myasthenia gravis

BB8 has no muscles (MG) and keeps his cool (no adrenals)

Question 3

HLA B27 (PAIR)

Answer 3

P- psoriatic arthritis
A- ankylosing spondy
I- IBD
R- reactive arthritis

Question 4

HLA DQ2/8

Answer 4

Celiacs

I ate (8) too (2) much gluten at Dairy Queen.

Question 5

HLA DR2

Answer 5

MS
SLE
Goodpasture
Hay fever

Two DoctoRs said that MS. Lupus’s Good Pastures are covered in Hay.

Question 6

HLA DR3

Answer 6

Type 1 DM
Graves
Hashimoto

Three doctors dug 1 GRAVE for HASHIMOTO

(Addison’s)
(SLE)

Question 7

HLA DR4

Answer 7

Rheumatoid arthritis
There are 4 walls in a “rheum”

(Type 1 DM)
(Addison’s)

Question 8

HLA DR5

Answer 8

Pernicious anemia

Hashimoto thyroiditis

Question 9

What two HLA types are associated with type 1 DM?

Answer 9

HLA DR3/4

Question 10

Fragile X

Answer 10

CGG

Question 11

Friedreich Ataxia

Answer 11

CAA (AA for AtAxia)

Question 12

Huntington

Answer 12

CAG (looks like CAuGht = hunting)

Question 13

MyoTonic dystrophy

Answer 13

CTG (tonic for T)

This is the: My Tonia, My Testicles, My Toupee, My Ticker (for balding and arrhythmias) from the DMPK gene