Oncology Flashcards
What conditions are associated with Non-hodgkin lymphoma?
Wiskott-Aldrich, Ataxia Telangectasia, X-linked lymphoproliferative disorder,
HIV, immunosuppression
What are the presenting features of Hodgkins lymphoma classically?
Fever, weightloss >10%, drenching nightsweat. Lymphadenopathy, cervical or axilla
Where do neuroblastomas come from?
Anywhere along sympthetic chain BUT
2/3 arise in abdomen.
What is pathagnomic for neuroblastoma?
Raised urinary catecholamines
(adrenaline, dopamine, HVA, VMA)
How do nephroblastomas typically present?
Inicdental finding of mass in flank in 2-4 yr old.
How do hepatoblastomas typically present?
R sided abdominal mass <6 years
What test is pathagnomic for hepatoblastoma?
Rasied AFP
How do osteoscarcomas typically present?
What does x-ray show?
Painful swelling of long bone in 12-16 year old.
Lytic lesions
What are the laboratory findings of tumour lysis syndrome?
Rasied K+, PO4- and Purines
Later hypoclacaemia
What is the treatment for tumour lysis syndrome?
Hyperhydration and Rasburicase
What cell may you find in biopsy of hodgkins lymphoma?
Reed-sternberg cells.
(Bi-lobed nucleii + ‘owls eye’ appearance)
Nephroblastoma is associated with what condtion?
Beckwith-Wiedmann Syndrome
WAGR
What is the long term side effect of prednisolone in context of oncology?
Avascular necrosis of hip
What is the short term side effect of vincristine?
Peripheral neuropathy
Constipation
What is the short term side effect of Doxyrubicin/ anthracycline?
Cardiomyopathy
Needs repeat echo 3-5 years for life
