Immunology Flashcards
What are the features and inheritence of Wiskott-Aldritch syndrome?
X-linked recessive
Thrombocytopenia, eczema, combined immunodeficiency and therefore recurrent skin and sinopulmonary infections.
What are the features and inheritence of Ataxia Telangectasia syndrome?
A.R.
Progressive neurology (ataxia), telangectasia -eyes especially, recurrent sinopulmonary infections
Define congenital neutropenia
<0.5 x10(9) Neutrophils > 3 months
What are your differentials for a relapsing fever?
Familial mediterranean fever
Lyme disease
Cyclical Neutropenia
T.B.
Systemic Jouvenile Idiopathic Arthritis
Baby that is getting severe symptoms from rotavirus vaccine suggests what?
Severe Combined Immunodeficiency Syndrome
What type of blood products do patients with SCID OR about to have HSCT require?
CMV negative, immunodepleted, irradiated products.
What are the features and inheritance of Chronic Granulomatous Disease?
X-linked defect in phagocytes
Recurrent infection, poor wound healing, IBD symptoms
What are the features and inheritence of X-linked agammaglobulinaemia?
X-linked
Abnormal development of B-cells
Recurrent infections with encapsulated bacteria > 6month age
What immunodeficiency is commonly found incidentally as part of coeliac screen?
Selective IgA deficiency
Recurrent infections and delayed seperation of umbilical chord after birth suggest what?
Leukocyte adhesion deficiency
How do you categorise bacteria ?
gram stain
shape
aneaerobe/aerobe
spore
What are the features of streptacoccal bacteria?
gram positive, cocci, aerobic, no spore
How would you categorise listeria?
gram positive, baccili, aerobic, no spore
what is the only gram negative cocci?
Neisseria
What are the gram negative, aerobic or facultative aerobic bacilli?
e.coli, klebsiella, shigella, salmonella, haemophilus
pseudomonas- full aerobe
