Oncology

Question 1

Bleomycin

Answer 1

A cytotoxic agent that can cause lung fibrosis

Question 2

HPV 6 and 11

Answer 2

Non-carcinogenic but associated with genital warts

Question 3

CEA

Answer 3

Carcinoembryonic antigen is a tumour marker for colorectal cancer and used to monitor disease activity

Question 4

Cisplatin

Answer 4

Associated with hypomagnesaemia which can cause seizures

Question 5

Kartagener’s syndrome

Answer 5

Immotile cilia associated with recurrent sinusitis and liver in the upper left quadrant

Question 6

Lynch syndrome

Answer 6

Autosomal dominant condition that leads to high rates of colorectal cancer

Question 7

MEN type IIb

Answer 7

Associated with pheochromocytomas and is autosomal dominant

-medullary carcinoma of the thyroid

Question 8

Methotrexate

Answer 8

Associated with myelosuppression, liver fibrosis and mucositis

Question 9

Doxorubicin

Answer 9

Associated with cardiomyopathy as it is an anthracycline

Question 10

Neoplastic spinal cord compression

Answer 10

High dose oral dexamethasone and then MR scan

Question 11

CA 19-9

Answer 11

Can be used to monitor pancreatic cancer disease activity

Question 12

PET scan

Answer 12

Shows the degree of glucose uptake by cells

Question 13

Calcitonin

Answer 13

Tumour marker for medullary thyroid cancer

Question 14

Gardeners syndrome (FAP)

Answer 14

• autosomal dominant
• may develop retroperitoneal desmoid tumours
• increased risk of malignancy due to polyps
• increased risk of thyroid cancer
• APC gene mutation

Question 15

Lung adenocarcinoma

Answer 15

• most common in non-smokers

- peripheral lesion

Question 16

Dexamethasone

Answer 16

Used to supress nausea and vomiting with intracranial tumours

Question 17

Spinal cord compression

Answer 17

Back pain is the earliest and most common symptom

Question 18

CA 15-3

Answer 18

Tumour marker used to monitor breast cancer

Question 19

Squamous cell lung cancer

Answer 19

Strong association with smoking and occurs centrally around the bronchus

Question 20

Bone metastases

Answer 20

In women this is most likely to come from breast cancer

Question 21

Suspected neoplastic spinal cord compression

Answer 21

Need whole spin MR scan

Question 22

SVCO

Answer 22

Most commonly caused by small cell lung cancer

Question 23

Nivolumab

Answer 23

An immune checkpoint inhibitor used to treat solid cancers