Objectives 12-15 Flashcards
true or false? each neurotransmitter can bind to several receptors?
true
this type of pharmaceutical does what the neurotransmitter does: it works with it
agonist
this type of pharmaceutical blocks the neurotransmitter from acting: the effect is the opposite of what the neurotransmitter does
antagonist
what are the two ways a neurotransmitter is removed from the synaptic cleft?
degradation and reuptake
what does acetylcholine effect?
PNS effectors, skeletal muscle, CNS
how is acetylcholine removed from the synapse?
the enzyme acetylcholinesterase
what kind of receptors does acetylcholine act at?
2 different cholinergic receptors
what are the 2 different cholinergic receptors that acetylcholine acts at?
nicotinic and muscarinic
where are nicotinic receptors found?
neuromuscular junction; some parts of CNS
what do nicotinic receptors cause, when activated?
skeletal muscle contraction
where are muscarinic receptors found?
on parasympathetic target organs
what do muscarinic receptors cause, when activated?
lower heart rate and lower BP, constricted pupils, digestion
which neurotransmitter is associated with Alzheimer’s? in what level?
lower levels of acetylcholine
where do epinephrine and norepinephrine have an effect?
sympathetic nervous system
how are epinephrine and norepinephrine removed from the synapse?
reuptake and enzyme MAO (monoamine oxidase)
what are the receptors for epinephrine and norepinephrine?
a and b adrenergic receptors
what do alpha adrenergic receptors do?
vasoconstriction, increase blood pressure, pupil dilation
what do beta adrenergic receptors do?
increase heart rate, open airways
how is serotonin removed from the synaptic cleft?
reuptake
this neurotransmitter is excitatory to muscles, regulates food intake, reproductive activity, and plays a role in mood and anxiety
serotonin
how do MAOI drugs work?
inhibit MAO, increasing epinephrine and norepinephrine in the synapse