O&G 2 Flashcards
Combined screening test (test + timing)
- US
- nuchal translucency
- serum tests (bhCG, PAPP-A) Not: AFP (used for neural tube defects)
done at 11-12 weeks
Terminology with screening
there is a CHANCE of something happening -> do not say risk
based on Down syndrome Society
people have different tolerances of what chance they are
Diagnostic tests for foetal abnormalities (invasive)
CVS and amniocentesis
When are CVS and amniocentesis done
CVS: (early) - 11-14w
amnio: 15w-18w (fetal cells shed into the amniotic fluid)
CVS issues
- 0.5 - 2% risk of miscarriage
- moscaiicm - may have patches of maternal tissue, normal tissue
- insufficient sample
- Infection 0.1%
- local reaction: pain and bleeding
full karyoteyp takes 2 w
prelim results are PCR
more spontaneous miscarriages in early pregnancy so CVS > amanio ? check if the procedure risk is the one that a os stated
only people with risk of trisomies >150 chance will be offered CVS aaamnio
or if the couple had aa previous pregnancy affected
anomaly scan - when?
around 20w
what anomalies does the 20w scan look for?
- neural tube defects
- cleft lip/palate
- cystic lesions in neck and lungs
- pulmonary malformations
- renal agenesis
- hydronephrosis
- hyperechogenic bowel can be associated with CF or the baby having swallowed some blood
- limbs: any signs of short limbs
- cord too check if there are 2 or 3 vessels in it
Not:
- hand digits
What is the next step if an anomaly is detected during the anomaly scan?
Referral to foetal medicine unit
What should you offer to calculate in PACES questions on IUGR/SGA?
GA based on mums EDD from USS
Late foetal loss
22-24w
immediate postpartum death within 7 days
early neonatal death
neonatal death 7d-1y post birth
late neonatal death
is the definition of neonatal death GA dependant?
no - can be termed this regardless of GA
IUD - what form of delivery is recommended?
vaginal
- helps with the grief, to allow time for the grief to develop and it might feel surreal if the pregnancy ends with an operation
Steps after miscarriage?
stop smoking
normalise BMI
genetic testing? counselling?
optimise any health conditions
offer early pregnancy scan at 6-7 weeks
not earlier because many not be seen and can cause a lot of stress
Breaking bad news
Mx of chronic hypertension in pregnancy
- additional antenatal appts (weekly, 2- or 4-weekly based on pts needs)
- stop ACEi and ARBs within 2 working days of notification of pregnancy and offer alternatives
- start aspirin 75-150 mg OD from 12w for PE prophylaxis
- offer anti-HTN treatment if BP > or = 140/90 mmHg
use LABETOLOL, NIFEDIPINE or METHYLDOPA
aim BP < or = 135/85 mmHg
fetal monitoring in chronic HTN in pregnancy
at 28, 32 and 36w carry out
- USS fetal growth and amniotic fluid
- umbilical artery doppler velocimetry
blood vessels inspected on fetal USS
- MCA
- umbilical A
- ductus venosus
- ???
When should aspirin be started in pregnant women with chronic HTM and what is the purpose?
at 12 w
to prevent pre-ecclampsia from developing
What dose of aspirin should be given to pregnant women with chronic HTN to prevent pre-ecclapmsia?
75-150 mg OD
Which anti-HTM meds are given to women with chronic HTN in pregnancy?
Labetalol
Nifedipine
Methyldopa
MoA Labetalol?
dual a1 and b1/b2 adrenergic receptor antagonist
Which meds can be prescribed for gestational HTN?
labetalol
nifedipine
methyldopa
aim BP in gestational HTN
</= 135/85
Blood tests in gestational HTN
FBC
LFTs
Renal function
at presentation and then weekly
What anti-HTN medication in pregnancy is contraindicated if the patient has asthma?
Labetalol
therefore use nifedipine instead
What anti-HTN for gestational HTN is contraindicated in a PMH of depression?
methyldopa
Define gestational HTN
BP >140/90 mmHg in pregnancy with no hx of HTN when not pregnant.
without proteinuria
should resolve within 6w PP
What are the main risks associated with untreated gestational HTN?
- IUGR
- pre-eclampsia
- placental abruption
What is vasa praevia?
Condition where foetal blood vessels run across the internal os of the cervix
presents typically with heavy, painless PV bleeding during labour -> Obs emergency b/c foetus loses O2 supply and CTG trace deteriorates -> em CS
What are risk factors for vasa praevia?
- IVF
- multiple pregnancy
Most common benign cause of postmenopausal PV bleeding
atrophic vaginitis
investigations in postmenopausal PB bleeding
- TVUS!!!! measure the thickness of the endometrium (>4mm would be abnormal and warrants endometrial biopsy)
What underlying conditions can increase the endometrial thickness in postmenopausal women and should be addressed?
obesity
T2DM
sx of obstetric choleostasis
itching of palms and soles, worse at night with no rash
deposition of bile salts in the skin causes itching
jaundice
pale stools
dark urine
in severe cases the lack of bile in the intestine can cause malabsorption of vitamin K and bleeding therefore.
supported by deranged LFTs and raised bile acids in blood
Risks associated with obstetric cholestasis
- premature birth
- stillbirth
- meconium passage
-> therefore close monitoring
Mangement of PID
Abx:
ceftriaxone (1g IM stat), doxycycline (100 mg PO BD for 14d), metronidazole (400 mg PO BD for 14d) -> given right away
review after 72h
consider removing copper IUD/IUS if in situ sx still present after 72h
What glucose measurement should be done for pts with a hx of gdm?
2h OGTT
risk factors for stress incontinence
- increased age
- multiparity
- traumatic delivery
- obesity
Mx of stress incontinence
1st line: 3 months of pelvic floor physiotherapy/exercises
Duloxetine (SNRI) 40 mg BD is used for depression but can also be used as an adjunct to pelvic floor exercises as it increases the activity of the urethral sphincter
if exercises +/- duloxetine is ineffective/unacceptable -> surgery (urethral bulking agents, autologous fascial slings, Burch colposuspension)
Considerations for pregnant women to avoid toxoplasmosis
- wash fruit and vegetables thoroughly!!
- do not handle cat faeces
- avoid unpasteurised milk (products)
- avoid raw or undercooked meat
mnemonic for congenital infections associated with morbidity and mortality
TORCH
Toxoplasmosis
Others (Varicella, listeria)
Rubella
Cytomegalovirus
Herpes simplex virus
What does toxoplasmosis in pregnancy cause?
- most babies will have no gross congenital abnormalities but have delayed neurological developmental sequelae (e.g. developmental delay, epilepsy. blindness, deafness)
Surgical ToP methods
- MVA: used up to 14w (cervix may be ripened with misoprostol; vacuum, suction used to evacuate the uterine cavity)
- dilatation and evacuation: over 14 w (the cervix has to be dilated more in order to remove larger foetal parts; contents of uterus are evacuated sing forceps and vacuum) USS used to confirm complete evacuation
What is symphysis pubis dysfunction?
pelvic girdle pain
pain associated with excessive movement of the pubic symphysis due to laxity of the pelvic ligaments
Mx of pelvic girdle pain in pregnancy
conservative: exercise to strengthen the surrounding muscles, warm baths, support belts.
Medical: paracetamol
Why should ibuprofen be avoided in pregnancy?
because it is associated with an increased risk of miscarriage; before 30w it may be considered in rare cases where the benefits outweigh the risks.
after 30w it should be avoided because NSAIDs may cause premature closure of the ductus arteriosus, persistent pulmonary hypertension of the newborn and oligohydramnios
What can codeine in the 3rd trimester cause?
neonatal withdrawal syndrome
neonatal respiratory distress
What are the components of the risk malignancy index in ovarian cancer?
Ca-125
menopause status
USS findings
Which USS findings contribute to a higher risk of ovarian cancer?
- multioculated cysts
- solid areas
- bilateral lesions
- ascites
- intra-abdominal metastases
Mx of ovarian cacner
- depends on stage
mainstay is a total hysterectomy +bilateral sapling-oophrectomy with or without platinum based chemotherapy
Are biopsies performed in ?ovarian cancer?
No
because disrupting the surface of the mass may increase the risk of metastasis
Which ovarian cancer subtype would cause changes in a blood hormone profile and what change?
granulose cell tumours may cause a high oestrogen level
What does HRT increase the risks of?
VTE
Breast cancer
endometrial cancer
gallbladder disease
What conditions does HRT decreases the risks of?
colorectal cancer
osteoporosis
what does baseline bradycardia on CTG indicate?
cord prolapse, epidural/spinal anaesthesia, rapid foetal descent
what does baseline tachycardia on CTG indicate?
maternal pyrexia, hypoxia, prematurity