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Year 5 😊✌🏼 > Liver CPC > Flashcards

Liver CPC Flashcards

1
Q

Functions of the liver

A

Intermediary metabolism
Protein synthesis
Xenobiotic metabolism
hormone metabolism
Bile
reticuloendothelial function (immune modulation, clearance of infection and LPSs, Ag presentation, erythropoiesis)

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2
Q

What are LFTs?

A
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3
Q

Liver anatomy

A
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4
Q

What do ALT and AST do?

A

ALT: amino acid metabolism and switching amino acids

AST:

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5
Q

ALT - where is it found?

A

liver
muscle
brain
pancreas

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6
Q
A

ALT goes up more than AST in liver damaahe

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7
Q

AST:ALT ratio

A

> 2.0 in alcohol suggests advanced diseasea

in absence of alcohol:

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8
Q

What does gamma GT do>

A

amino acid metabolism

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9
Q

Where is GGT found?

A

liver, kidney, pancreas, spleen, heart, brain, seminal vessels, duct

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10
Q

ALP - where is it localised?

A

sinusoidal and caclicular membranes.

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11
Q

ALP - where is it localised?

A

sinusoidal and caclicular membranes.

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12
Q

Causes of ALP raised

A

bone
small intestine
kidney
WBC
placenta (pregnancy!)

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13
Q

half life of albumin

A

20dq

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14
Q
A

INR for acute

albumin is a marker for chronic liver disease

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15
Q

AFP

A

tumour marker
increased in hepatocellular carcinoma raised in hepatic damage
raised in testicular cancer.

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16
Q

Why pale stools in obstructive?

A

bile not passing through

xxx

17
Q

Liver panel - investigations?

A

fasting
coeliac serology
hepatitis serology (HBV surface, HCV)
alpha-1-antitrypsin
ceruloplasmin (if <50yo)
Liver AAbs (LKM, aSMA, AMA)
Immunoglobulins
Ferritin
ANCA

18
Q

what ceruloplsamin is diagnostic of Wilsons disease?

A

low

19
Q

Is haemochromatosis common?

A

relatively common

presents earlier in men
managed with venesection

20
Q

fibroscan

A

can tell you how fibrotic a liver is

21
Q

ELF

A

enhanced liver fibrosis scan

22
Q

Hep A sx

A

diarrhoeal illness
…

Year 5 😊✌🏼 (53 decks)

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