NSAIDs (M2) Flashcards

1
Q

What do the COX-1 and COX-2 pathways directly form? 1. What do these eventually generate? 2

A
  1. PGG2 and PGH2

2. prostaglandins, thromboxane, and prostacyclin

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2
Q

What does the LOX pathway directly form? 1. What do these eventually generate? 2

A
  1. HPETEs

2. HETEs and leukotrienes

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3
Q

What are the validated combined indices developed for Rheumatoid Arthritis?

A
  1. Disease Activity Index

2. American College or Rheumatology Response Index

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4
Q

Which NSAID is the least effective?

A

aspirin

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5
Q

Which NSAID is not effective for gout treatment?

A

Tolmetin

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6
Q

Which NSAID has high BI and renal side effects?

A

Ketorolac

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7
Q

Which NSAID use results in liver function abnormalities?

A
  1. Diclofenac

2. Sulindac

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8
Q

Which NSAIDs have the greatest toxicity?

A
  1. indomethacin

2. tolmetin

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9
Q

Which NSAIDs have the least toxicity?

A
  1. aspirin
  2. salsalate
  3. ibuprofen
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10
Q

Which NSAIDs are best to use if there is renal insufficiency?

A

nonacetylated salicylates

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11
Q

What is the progression of rheumatoid arthritis?

A
  1. Immune system attacks synovium
  2. Inflammation destroys cartilage and bone
  3. tendons and ligaments weaken and stretch
  4. joint loses its shape
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12
Q

What are deposits of crystalline uric acid at the surface of joints, in skin or cartilage, as a feature of gout?

A

Tophi

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13
Q

What are episodes of acute arthritis due to deposits of monosodium urate in joints and cartilage?

A

gout

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14
Q

What are the side effects of gout?

A
  1. uric acid calculi
  2. tophi
  3. interstitial nephritis
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