NSAIDs (M2) Flashcards
What do the COX-1 and COX-2 pathways directly form? 1. What do these eventually generate? 2
- PGG2 and PGH2
2. prostaglandins, thromboxane, and prostacyclin
What does the LOX pathway directly form? 1. What do these eventually generate? 2
- HPETEs
2. HETEs and leukotrienes
What are the validated combined indices developed for Rheumatoid Arthritis?
- Disease Activity Index
2. American College or Rheumatology Response Index
Which NSAID is the least effective?
aspirin
Which NSAID is not effective for gout treatment?
Tolmetin
Which NSAID has high BI and renal side effects?
Ketorolac
Which NSAID use results in liver function abnormalities?
- Diclofenac
2. Sulindac
Which NSAIDs have the greatest toxicity?
- indomethacin
2. tolmetin
Which NSAIDs have the least toxicity?
- aspirin
- salsalate
- ibuprofen
Which NSAIDs are best to use if there is renal insufficiency?
nonacetylated salicylates
What is the progression of rheumatoid arthritis?
- Immune system attacks synovium
- Inflammation destroys cartilage and bone
- tendons and ligaments weaken and stretch
- joint loses its shape
What are deposits of crystalline uric acid at the surface of joints, in skin or cartilage, as a feature of gout?
Tophi
What are episodes of acute arthritis due to deposits of monosodium urate in joints and cartilage?
gout
What are the side effects of gout?
- uric acid calculi
- tophi
- interstitial nephritis