Antiprotozoal and Antihelmithic Drugs (M3) Flashcards
What is the most important parasitic disease of humans?
malaria
Which species of Plasmodium (malaria) cause the most serious complications and deaths?
P. flaciparium
For malaria, what are the organisms called that invade the cells? 1. What cells do they invade? 2. What is their replication called? 3
- sporozoites
- liver cells
- schizogony
Which state of the protozoa causes clinical malaria?
asexual erythrocytic state of infection
Which stage of parasites in malaria invade erythrocytes?
merozoite
What stage of parasites do mosquitoes take up?
gametocytes
What are the malaria drugs called that eliminate developing or dormant liver forms?
tissue schizonticides
What are the malaria drugs called that act on erythrocytic parasites?
blood schizonticides
What are the malaria drugs called that kill sexual stages and prevent transmission to mosquitoes?
gametocides
What is the drug combo with sulfadoxine and pyrimethamine called?
fansidar
What is the drug combo with dapsone and pyrimethamine called?
maloprim
What is the first line therapy combo for toxoplasmosis?
pyrimethamine with sulfadiazine
What is an infection with entamoeba histolytica called? 1. What does it cause? 2
- Amebiasis
2. colitis, dysentery, ameboma, liver abscess
What are some of the other antiprotozoal drugs?
pentamidine, sodium stiboguconate, nitazoxanide, suramin, melarsoprol, eflornithine, benznidazole, nifurtimox, amphotericin, miltefosine, paromomycin
What are the multicellular organisms that indclude nematodes, flukes, tapeworms?
helminths