Drugs Used in Parkinson's (M3) Flashcards
What are the abnormal movements associated with Parkinson’s?
- tremor
- chorea
- athetosis
- tics
What are the parts of the brain that are the most effected by Parkinson’s?
- cortex
- thalamus
- basal ganglia
What is the specific area of the brain that is degenerated by Parkinson’s?
pars compacta
What is the problems associated with a resting tremor? 1. An intention tremor? 2
- Parkinson’s
2. lesion of brainstem or cerebellum, drug toxicity
What are slow, writhing movements associated with Parkinson’s called?
athatosis
What are abnormal postures when sustained called?
dystonia
What is the symptom of Parkinson’s that is characterized by shorter steps, difficulty getting out of chair, and feet draging?
bradykinesia
What are the five stages of Parkinson’s damage according to the Braak scale?
- lower brainstem
- higher brainstem
- substantia nigra
- mesocortex and thalamus
- entire cortex
What type of neurons are selectively lost during Parkinson’s?
dopaminergic neurons that normally inhibit GABAergic output
What are the other major movement disorders?
- Huntington’s disease
- Tics (Gilles de la Tourette’s Syndrome)
- Tardive Dyskinesia
For Huntington’s disease, where is GABA reduced?
basal ganglia
For Huntington’s disease, what is specifically reduced?
choline actylthransferase
For Huntington’s, what is the chorea a result of?
overactivity in dopaminergic nigrostriatal pathways