Drugs Used in Parkinson's (M3) Flashcards

1
Q

What are the abnormal movements associated with Parkinson’s?

A
  1. tremor
  2. chorea
  3. athetosis
  4. tics
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2
Q

What are the parts of the brain that are the most effected by Parkinson’s?

A
  1. cortex
  2. thalamus
  3. basal ganglia
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3
Q

What is the specific area of the brain that is degenerated by Parkinson’s?

A

pars compacta

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4
Q

What is the problems associated with a resting tremor? 1. An intention tremor? 2

A
  1. Parkinson’s

2. lesion of brainstem or cerebellum, drug toxicity

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5
Q

What are slow, writhing movements associated with Parkinson’s called?

A

athatosis

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6
Q

What are abnormal postures when sustained called?

A

dystonia

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7
Q

What is the symptom of Parkinson’s that is characterized by shorter steps, difficulty getting out of chair, and feet draging?

A

bradykinesia

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8
Q

What are the five stages of Parkinson’s damage according to the Braak scale?

A
  1. lower brainstem
  2. higher brainstem
  3. substantia nigra
  4. mesocortex and thalamus
  5. entire cortex
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9
Q

What type of neurons are selectively lost during Parkinson’s?

A

dopaminergic neurons that normally inhibit GABAergic output

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10
Q

What are the other major movement disorders?

A
  1. Huntington’s disease
  2. Tics (Gilles de la Tourette’s Syndrome)
  3. Tardive Dyskinesia
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11
Q

For Huntington’s disease, where is GABA reduced?

A

basal ganglia

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12
Q

For Huntington’s disease, what is specifically reduced?

A

choline actylthransferase

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13
Q

For Huntington’s, what is the chorea a result of?

A

overactivity in dopaminergic nigrostriatal pathways

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