Dyslipidemia Drugs (M2) Flashcards

1
Q

What is elevation in any lipoprotein called?

A

hyperlipoproteinemia or hyperlipidemia

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2
Q

What is increased levels of triglycerides called?

A

hyperlipemia

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3
Q

What are the major clinical problems associated with hyperlipidemia?

A
  1. acute pancreatitis

2. atherosclerosis

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4
Q

What are foam cells in atherosclerotic plaques made of?

A

transformed macrophages

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5
Q

What are the roles of High-density Lipoproteins (HDL)?

A
  1. retrieve cholesterol from artery wall (from cells and macrophages) and bring to liver
  2. inhibit oxidation of atherogenic lipoproteins
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6
Q

What are some of the impacts that smoking has, making coronary disease more likely?

A
  1. reduced HDL
  2. cytotoxic effects on endothelium
  3. increased oxidation of lipoproteins
  4. stimulation of thrombogenesis
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7
Q

What hydrolyzes chylomicrons to form triglycerides?

A

lipoprotein lipase (LPL)

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8
Q

What is the process of VLDL becoming LDLs and IDLs?

A
  1. accept apoproteins C and E from HDLs
  2. export triglycerides to peripheral tissues
  3. Hydrolyzed by lipoprotein lipase (LPL)
  4. Return apoproteins C and E to HDLs
  5. Transformed to LDLs and IDLs
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9
Q

What is the function of LDLs?

A

yield free cholesterol for synthesis of cell membranes

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10
Q

What forms Lp(a) Lipoprotein? 1. What is it conected by? 2. Where are these found? 3

A
  1. LDL and the (a) protein
  2. disulfide bridge
  3. atherosclerotic plaques
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11
Q

What secretes HDL?

A

liver and intestines

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12
Q

What does sucrose and fructose raise in the body?

A

VLDL

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13
Q

What does cholesterol and saturated and trans fats increase in the body?

A

LDL

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