Dyslipidemia Drugs (M2) Flashcards
What is elevation in any lipoprotein called?
hyperlipoproteinemia or hyperlipidemia
What is increased levels of triglycerides called?
hyperlipemia
What are the major clinical problems associated with hyperlipidemia?
- acute pancreatitis
2. atherosclerosis
What are foam cells in atherosclerotic plaques made of?
transformed macrophages
What are the roles of High-density Lipoproteins (HDL)?
- retrieve cholesterol from artery wall (from cells and macrophages) and bring to liver
- inhibit oxidation of atherogenic lipoproteins
What are some of the impacts that smoking has, making coronary disease more likely?
- reduced HDL
- cytotoxic effects on endothelium
- increased oxidation of lipoproteins
- stimulation of thrombogenesis
What hydrolyzes chylomicrons to form triglycerides?
lipoprotein lipase (LPL)
What is the process of VLDL becoming LDLs and IDLs?
- accept apoproteins C and E from HDLs
- export triglycerides to peripheral tissues
- Hydrolyzed by lipoprotein lipase (LPL)
- Return apoproteins C and E to HDLs
- Transformed to LDLs and IDLs
What is the function of LDLs?
yield free cholesterol for synthesis of cell membranes
What forms Lp(a) Lipoprotein? 1. What is it conected by? 2. Where are these found? 3
- LDL and the (a) protein
- disulfide bridge
- atherosclerotic plaques
What secretes HDL?
liver and intestines
What does sucrose and fructose raise in the body?
VLDL
What does cholesterol and saturated and trans fats increase in the body?
LDL