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Pharm I > NSAIDs > Flashcards

NSAIDs Flashcards

1
Q

Asprin aka

A

acetylsalicylic acid

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1
Q

Acetylsalicylic acid adverse effects

A

prolonged bleeding time
GI irritant - not to be used in gastric ulcerative conditions

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2
Q

Acetylsalicylic acid metabolism

A

metabolized to salicylic acid in the liver

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3
Q

Consideration when administering acetylsalicylic acid

A

consider when last dose was before performing surgery
do not use in patients with possible spinal cord trauma

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4
Q

Phenylbutazone MOA

A

non-selective COX inhibitor

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5
Q

Phenylbutazone therapeutic uses

A

anti-inflammatory in horses and dogs
osteoarthritis
laminitis
colic

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6
Q

Phenylbutazone adverse effects

A

hepatic toxicity
GI ulceration
bone marrow hypoplasia
renal papillary necrosis
more toxic to foals
promotes Na+ and water retention - caution in cardiovascular patients
depression in dogs

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7
Q

Phenylbutazone metabolism

A

metabolized in liver to oxyfenbutazone

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8
Q

Is phenylbutazone okay to use in dairy cattle?

A

no - prohibited in dairy cows older than 20 months
which can cross the placenta and be detected in milk

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9
Q

Flunixin megluamine MOA

A

non-selective COX inhibitor
blocks prostanoid synthesis related to endotoxemia

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10
Q

Flunixin megluamine therapeutic use

A

horses: musculoskeletal anti-inflammatory, colic, endotoxic shock
cattle: acute mastitis, acute pulmonary emphysemia, endotoxemia
dogs: septic shock
swine: control pyrexia associated with respiratory disease

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11
Q

Flunixin megluamine withdrawal period in cattle and swine

A

4 days in cattle
12 days in swine

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12
Q

Can flunixin megluamine be used in dairy cows and veal calves?

A

NOOOO

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13
Q

Naproxen MOA

A

non-selective COX inhibitor

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14
Q

Naproxen therapeutic use

A

myositis
soft-tissue inflammation
good for horses

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15
Q

Naproxen metabolism

A

enterohepatic circulation - prolonged elimination half-life

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16
Q

Ibuprofen MOA

A

non-selective COX inhibitor

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17
Q

Ibuprofen adverse effects

A

NOT recommended for dogs
GI disturbances
vomiting

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18
Q

Meclofenamic acid MOA

A

NSAID
slow onset

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19
Q

Meclofenamic acid therapeutic uses

A

preferred for horses

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20
Q

Ketoprofen adverse effects

A

GI upset
nephritis

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21
Q

Ketoprofen therapeutic uses

A

used in horses, cattle, swine, dogs, cats
anti-inflammatory
analgesic
anti-pyretic
horses: musculoskeletal disorders

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22
Q

Ketoprofen MOA

A

inhibits COX and LOX
inhibits bradykinin

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23
Q

Diclofenac therapeutic use

A

horses: osetoarthritis in limbs
topical cream

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24
Q

Carprofen MOA

A

COX-2 inhibitor
inhibits phospholipase - blocks release of arachidonic acid

25
Q

Carprofen therapeutic use

A

for dogs, cats, horses, cattle
osteoarthritis
post-op pain

26
Q

Carprofen adeverse effects

27
Q

Carprofen metabolism

A

metabolized in the liver
excreted in the feces
enterohepatic recycling

28
Q

Meloxicam MOA

A

COX-2 inhibitor

29
Q

Meloxicam therapeutic use

A

Dogs: osteoarthritis
Cats: post-op
pain and inflammation
associated with
orthopedic surgery,
ovariohysterectomy,
castration (pain for
surgeries)

30
Q

Piroxicam MOA

A

inhibits new blood vessel formation

31
Q

Piroxicam therapeutic use

A

osteoarthtitis in dogs
transitional cell tumors
musculoskeletal inflammatory conditions

32
Q

Deracoxib MOA

A

COX-2 inhibitor

33
Q

Dercoxib therapeutic use

A

osteoarthitis
post-op orthopedic and dental pain
mostly used in dogs

34
Q

Dercoxib bioavailability

A

imoroved when administered with food

35
Q

Firocoxib MOA

A

COX-2 inhibitor

36
Q

Firocoxib therapeutic use

A

Dog: inflammation associated
w/ osteoarthritis, and
soft-tissue surgery
Horses: control pain and
inflammation with
osteoarthritis
—use
recommended for 14
days

37
Q

How old must a dog be in order to be prescribed firocoxib?

A

for use in dogs weighing more than 12.5lbs and 7months of age or older

38
Q

Robenacoxib aka

39
Q

Robenacoxib MOA

A

COX-2 inhibitor

40
Q

Robenacoxib therapeutic use

A

post-op pain and inflammation

41
Q

What animals is Robenacoxib approved for use in?

A

dogs and cats

42
Q

How old must a cat be in order to be prescribed robenacoxib?

A

for use in cats weighing more than 5.5lbs and are 4 months of age or older

43
Q

How long can cats be on robenacoxib?

A

no longer than 3 days

44
Q

Mavacoxib MOA

A

COX-2 inhibitor

45
Q

Mavacoxib therapeutic use

A

degenerative joint disease

46
Q

Half-life and dosing of mavacoxib

A

half-life of 17 days
do not exceed 7 doses

47
Q

Metabolism of mavacoxib

A

biliary excretion

48
Q

Tepoxalin MOA

A

COX and LOX inhibitor

49
Q

Tepoxalin therapeutic use

A

dogs: osteoarthitis

50
Q

Tepoxalin metabolism

A

metabolite = tepoxalin pyrazol acid
half-life 12-14 hours

51
Q

Etodolac MOA

A

COX-2 inhibitor
inhibit macrophage chemotaxis

52
Q

Etodolac therapeutic use

A

dogs: osteoarthitis

53
Q

Acetaminophen therapeutic use

A

analgesic
antupyretic

54
Q

Acetaminophen adverse effects

A

toxicity - emergency condition
cats: heptatoxic, methemoglobinemia

55
Q

Acetaminophen metabolism

A

toxic metabolite = NAPQI - CYP420 enzyme causing Heinz bodies = hepatotoxic

56
Q

Cimetidine MOA

A

inhibut metabolism of acetaminophen
H2 blocker

57
Q

Cimetidine therapeutic use

A

emergency treatment of acetaminophen toxicity

58
Q

N-acetly-cysteine MOA

A

precursor of glutathione
conjugates NAPQI - facilitates elimination

59
Q

N-acetly-cysteine therapeutic use

A

emergency treatment of acetaminophen toxicity

60
Q

When should N-acetly-cysteine be administered?

A

must be given before liver damage occurs

Pharm I (15 decks)

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