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Pharm I > Adrenergic Drugs > Flashcards

Adrenergic Drugs Flashcards

1
Q

Dopamine MOA

A

B1 agonist

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2
Q

Dopamine therapeutic use

A

Cardiogenic and septic shock

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3
Q

Dopamine Adverse Effects

A

Ischemic necrosis (extravasation)
Correct hypovolemia in patients under shock

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4
Q

Fendolopam MOA

A

D1 selective agonist - Gs protein

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5
Q

Fendolopam Therapuetic Use

A

Hypertensive crisis
Delayed diuresis (fel)

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6
Q

Dopexamine is

A

a synthetic dopamine analogue

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7
Q

Dopexamine MOA

A

Beta agonist (inotropic)

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8
Q

Dopexamine Therapeutic use

A

Cardiac failure

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9
Q

Methoxamine MOA

A

a1 agonist = vasoconstriction

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10
Q

Methoxamine Therapeutic Use

A

Hypotension during surgery

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11
Q

Methoxamine Adverse Effects

A

Hypertension
headache
vomiting

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12
Q

Metaraminol MOA

A

a1 agonist

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13
Q

Metaraminol Therapeutic Use

A

Hypotension during spinal anesthesia

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14
Q

Phenylephrine MOA

A

a1 agonist - direct

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15
Q

Phenylephrine Therapeutic Use

A

nasal decongestant
mydriatic - glaucoma

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16
Q

Phenylpropanolamine MOA

A

a1 agonist

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17
Q

Phenylpropanolamine Therapeutic Use

A

urinary incontinence in dogs - increase sphincter tone

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18
Q

Oxymetazoline MOA

A

a1 agonist, partial a2 agonist

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19
Q

Oxymetazoline Therapeutic Use

A

nasal decongestant

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20
Q

Clonidine MOA

A

a2 agonist CNS - suppresses sympathetic outflow

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21
Q

Clonidine Therapeutic Use

A

hypertension
preop sedation/analgesia

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22
Q

Clonidine Adverse Effects

A

dry mouth
sedation
rebound hypertension
bradycardia

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23
Q

Dobutamine MOA

A

b1 agonist

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24
Q

Dobutamine Therapeutic Uses

A

congestive heart failure

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25
Dobutamine Adverse Effects
increase AV conduction tachyphylaxis
26
Metaproterenol/Orciprenaline MOA
b2 agonist
27
Metaproterenol/Orciprenaline Therapeutic Use
bronchodilator
28
Terbutaline MOA
b2 agonist
29
Terbutaline Therapeutic Use
bronchodilator
30
Terbutaline Adverse Effects
tachycardia - not preffered in animals with heart disease
31
Albuterol/Salbutamol MOA
b2 agonist
32
Albuterol/Salbutamol Therapeutic Uses
bronchodilator
33
Clenbuterol MOA
b2 agonist
34
Clenbuterol Therapeutic Uses
bronchodilator COPD horses
35
Salmeterol MOA
b2 slow onset - long acting
36
Salmeterol Therapeutic Uses
bronchodilator
37
Isoxsuprine MOA
b2 agonist
38
Isoxsuprine Therapeutic Uses
navicular disease/laminitis in horses - vasdoilates skeletal muscle
39
Ritodrine MOA
b2 agonist
40
Ritodrine Therapeutic Uses
uterine relaxant - arrest premature labor
41
Ractopamine MOA
b2 agonist
42
Ractopamine Therapeutic Use
reparitioning agent for cattle and swine - increase muscle leanness
43
Ractopamine Adverse Effects
anorexia, bloat, locomotion disorder
44
Amphetamine MOA
peripheral a and b actions - release of catecholamines from vesicles
45
Amphetamine Therapeutic Use
stimulant in mood and alertness
46
Amphetamine Adverse Effects
insomia, tremor, restlessness excitement, agitation cardiac arrythmias GI signs
47
Ephedrine MOA
CNS stimulation - increase cardiac output and rate
48
Ephedrine Therapeutic Uses
bronchodilator hypotension nasal decongestant urinary incontinece myasthenia gravis
49
Ephedrine Adverse Effects
hypertension cardiac arrythmias insomnia tachyphylaxis
50
Phenoxybenzamine MOA
non-selective a antagonist inhibits reuptake of NE by presynaptic nerve terminals
51
Phenoxybenzamine Therapeutic Use
pheochromocytoma manage benign prostatic hypertrophy detrusor areflexia in dogs and cats
52
Phenoxybenzamine Adverse Effects
postural hypotension congestion, nausea, vomiting inhibit ejaculation and sperm production
53
Phentolamine MOA
non-selective a antagonist
54
Phentolamine Therapeutic Uses
hypertension associated with pheochromocytoma reverse oral local anesthetic
55
Phentolamine Adverse Effects
postural hypotension reflex tachycardia arrythmias diarrhea
56
Tolazoline MOA
non-selective a antagonist
57
Tolazoline Therapeutic Uses
reverse effects of Xylazine in large animals
58
Tolazoline Adverse Effects
arrythmias, tachycardia GI stimulation
59
Prazosin MOA
a1 antagonist
60
Prazosin Therapeutic Uses
hypertension benign prostate hypertrophy vasodilation
61
Prazosin Adverse Effects
dizziness nasal congestion headache drowsiness orthostatic hypotension
62
Terazosin MOA
a1 antagonist
63
Terazosin Therapeutic Use
vasodilator
64
Doxazosin MOA
a1 antagonist
65
Doxazosin Therapeutic Use
vasodilator
66
Yohimbine MOA
a2 antagonist in brain - release NE into synaptic cleft
67
Yohimhine Therapeutic Use
reversal agent of xylazine and detomidine
68
Atipamezole MOA
a2 antagonist
69
Atipamezole Therapeutic Use
reversal agent for dexmedetomidine and medetomidine (dogs)
70
Propranolol MOA
non-selective b antagonist
71
Propranolol Therapeutic Use
hypertension
72
Propranolol Adverse Effects
bronchoconstriction arrhythmias hypoglycemia
73
Timolol MOA
non-selective b antagonist
74
Timolol Therapeutic Use
glaucoma
75
Sotalol MOA
non-selective b antagonist
76
Sotalol Therapeutic Use
anti-arrhythmic drug
77
Carvedilol MOA
non-selective b antagonist
78
Metoprolol MOA
b1 antagonist
79
Metoprolol Therapeutic Use
hypertension ischemic heart disease thyrotoxicosis pheochromocytoma
80
Atenolol MOA
b1 antagonist
81
Acebutolol MOA
b1 antagonist
82
Acebutaolol Therapeutic Uses
hypertension ischemic heart disease thyrotoxicosis pheochromocytoma
83
Esmolol MOA
b1 antagonist
84
Esmolol Therapeutic Uses
hypertension ischemic heart disease thyrotoxicosis pheochromocytoma myocardial infraction

Pharm I (15 decks)

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