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Pharm I > Adrenergic Drugs > Flashcards

Adrenergic Drugs Flashcards

1
Q

Dopamine MOA

A

B1 agonist

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2
Q

Dopamine therapeutic use

A

Cardiogenic and septic shock

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3
Q

Dopamine Adverse Effects

A

Ischemic necrosis (extravasation)
Correct hypovolemia in patients under shock

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4
Q

Fendolopam MOA

A

D1 selective agonist - Gs protein

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5
Q

Fendolopam Therapuetic Use

A

Hypertensive crisis
Delayed diuresis (fel)

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6
Q

Dopexamine is

A

a synthetic dopamine analogue

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7
Q

Dopexamine MOA

A

Beta agonist (inotropic)

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8
Q

Dopexamine Therapeutic use

A

Cardiac failure

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9
Q

Methoxamine MOA

A

a1 agonist = vasoconstriction

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10
Q

Methoxamine Therapeutic Use

A

Hypotension during surgery

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11
Q

Methoxamine Adverse Effects

A

Hypertension
headache
vomiting

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12
Q

Metaraminol MOA

A

a1 agonist

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13
Q

Metaraminol Therapeutic Use

A

Hypotension during spinal anesthesia

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14
Q

Phenylephrine MOA

A

a1 agonist - direct

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15
Q

Phenylephrine Therapeutic Use

A

nasal decongestant
mydriatic - glaucoma

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16
Q

Phenylpropanolamine MOA

A

a1 agonist

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17
Q

Phenylpropanolamine Therapeutic Use

A

urinary incontinence in dogs - increase sphincter tone

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18
Q

Oxymetazoline MOA

A

a1 agonist, partial a2 agonist

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19
Q

Oxymetazoline Therapeutic Use

A

nasal decongestant

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20
Q

Clonidine MOA

A

a2 agonist CNS - suppresses sympathetic outflow

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21
Q

Clonidine Therapeutic Use

A

hypertension
preop sedation/analgesia

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22
Q

Clonidine Adverse Effects

A

dry mouth
sedation
rebound hypertension
bradycardia

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23
Q

Dobutamine MOA

A

b1 agonist

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24
Q

Dobutamine Therapeutic Uses

A

congestive heart failure

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25
Q

Dobutamine Adverse Effects

A

increase AV conduction
tachyphylaxis

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26
Q

Metaproterenol/Orciprenaline MOA

A

b2 agonist

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27
Q

Metaproterenol/Orciprenaline Therapeutic Use

A

bronchodilator

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28
Q

Terbutaline MOA

A

b2 agonist

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29
Q

Terbutaline Therapeutic Use

A

bronchodilator

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30
Q

Terbutaline Adverse Effects

A

tachycardia - not preffered in animals with heart disease

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31
Q

Albuterol/Salbutamol MOA

A

b2 agonist

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32
Q

Albuterol/Salbutamol Therapeutic Uses

A

bronchodilator

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33
Q

Clenbuterol MOA

A

b2 agonist

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34
Q

Clenbuterol Therapeutic Uses

A

bronchodilator
COPD horses

35
Q

Salmeterol MOA

A

b2
slow onset - long acting

36
Q

Salmeterol Therapeutic Uses

A

bronchodilator

37
Q

Isoxsuprine MOA

A

b2 agonist

38
Q

Isoxsuprine Therapeutic Uses

A

navicular disease/laminitis in horses - vasdoilates skeletal muscle

39
Q

Ritodrine MOA

A

b2 agonist

40
Q

Ritodrine Therapeutic Uses

A

uterine relaxant - arrest premature labor

41
Q

Ractopamine MOA

A

b2 agonist

42
Q

Ractopamine Therapeutic Use

A

reparitioning agent for cattle and swine - increase muscle leanness

43
Q

Ractopamine Adverse Effects

A

anorexia, bloat, locomotion disorder

44
Q

Amphetamine MOA

A

peripheral a and b actions - release of catecholamines from vesicles

45
Q

Amphetamine Therapeutic Use

A

stimulant in mood and alertness

46
Q

Amphetamine Adverse Effects

A

insomia, tremor, restlessness excitement, agitation
cardiac arrythmias
GI signs

47
Q

Ephedrine MOA

A

CNS stimulation - increase cardiac output and rate

48
Q

Ephedrine Therapeutic Uses

A

bronchodilator
hypotension
nasal decongestant
urinary incontinece
myasthenia gravis

49
Q

Ephedrine Adverse Effects

A

hypertension
cardiac arrythmias
insomnia
tachyphylaxis

50
Q

Phenoxybenzamine MOA

A

non-selective a antagonist
inhibits reuptake of NE by presynaptic nerve terminals

51
Q

Phenoxybenzamine Therapeutic Use

A

pheochromocytoma
manage benign prostatic hypertrophy
detrusor areflexia in dogs and cats

52
Q

Phenoxybenzamine Adverse Effects

A

postural hypotension
congestion, nausea, vomiting
inhibit ejaculation and sperm production

53
Q

Phentolamine MOA

A

non-selective a antagonist

54
Q

Phentolamine Therapeutic Uses

A

hypertension associated with pheochromocytoma
reverse oral local anesthetic

55
Q

Phentolamine Adverse Effects

A

postural hypotension
reflex tachycardia
arrythmias
diarrhea

56
Q

Tolazoline MOA

A

non-selective a antagonist

57
Q

Tolazoline Therapeutic Uses

A

reverse effects of Xylazine in large animals

58
Q

Tolazoline Adverse Effects

A

arrythmias, tachycardia
GI stimulation

59
Q

Prazosin MOA

A

a1 antagonist

60
Q

Prazosin Therapeutic Uses

A

hypertension
benign prostate hypertrophy
vasodilation

61
Q

Prazosin Adverse Effects

A

dizziness
nasal congestion
headache
drowsiness
orthostatic hypotension

62
Q

Terazosin MOA

A

a1 antagonist

63
Q

Terazosin Therapeutic Use

A

vasodilator

64
Q

Doxazosin MOA

A

a1 antagonist

65
Q

Doxazosin Therapeutic Use

A

vasodilator

66
Q

Yohimbine MOA

A

a2 antagonist in brain - release NE into synaptic cleft

67
Q

Yohimhine Therapeutic Use

A

reversal agent of xylazine and detomidine

68
Q

Atipamezole MOA

A

a2 antagonist

69
Q

Atipamezole Therapeutic Use

A

reversal agent for dexmedetomidine and medetomidine (dogs)

70
Q

Propranolol MOA

A

non-selective b antagonist

71
Q

Propranolol Therapeutic Use

A

hypertension

72
Q

Propranolol Adverse Effects

A

bronchoconstriction
arrhythmias
hypoglycemia

73
Q

Timolol MOA

A

non-selective b antagonist

74
Q

Timolol Therapeutic Use

75
Q

Sotalol MOA

A

non-selective b antagonist

76
Q

Sotalol Therapeutic Use

A

anti-arrhythmic drug

77
Q

Carvedilol MOA

A

non-selective b antagonist

78
Q

Metoprolol MOA

A

b1 antagonist

79
Q

Metoprolol Therapeutic Use

A

hypertension
ischemic heart disease
thyrotoxicosis
pheochromocytoma

80
Q

Atenolol MOA

A

b1 antagonist

81
Q

Acebutolol MOA

A

b1 antagonist

82
Q

Acebutaolol Therapeutic Uses

A

hypertension
ischemic heart disease
thyrotoxicosis
pheochromocytoma

83
Q

Esmolol MOA

A

b1 antagonist

84
Q

Esmolol Therapeutic Uses

A

hypertension
ischemic heart disease
thyrotoxicosis
pheochromocytoma
myocardial infraction

Pharm I (15 decks)

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