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Pharm I > Cholinergic Drugs > Flashcards

Cholinergic Drugs Flashcards

1
Q

Carbachol MOA

A

nicotinic and muscarinic agonist
stimulates autonomic ganglia - ACh release

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2
Q

Carbachol Therapeutic Uses

A

rumen atony and impaction in cattle
impaction colic in horses
glaucoma in dogs

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3
Q

Bethanechol MOA

A

muscarinic agonist

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4
Q

Bathanechol Therapeutic Use

A

uriniary retention

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5
Q

Pilocarpine MOA

A

M3 agonist - constraction of sphincter of iris and ciliary muscle of lens

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6
Q

Pilocarpine Therapeutic Use

A

glaucoma in dogs

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7
Q

Physostigmine MOA

A

reversible AChE inhibitor
indirect acting cholinergic agonist

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8
Q

Physostigmine Therapeutic Uses

A

glaucoma
antidote for atropine toxicity

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9
Q

Physostigmine Adverse Effects

A

large doses = convulsions

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10
Q

Neostigmine MOA

A

reversible AChE inhibitor
indirect acting cholinergic agonist

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11
Q

Neostigmine Therapeutic Use

A

myasthenia gravis
anti-curare

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12
Q

Neostagmine Adverse Effects

A

toxicity = skelteal muscle weakness

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13
Q

Edrophonium MOA

A

reversible AChE inhibitor
indirect cholinergic agonist

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14
Q

Edrophonium Therapeutic Use

A

diagnosis of myasthenia gravis

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15
Q

Edrophonium Adverse Effects

A

bradycardia

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16
Q

Pyridostigmine MOA

A

reversible AChE inhibitor
indirect cholinergic agonist
longer acting

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17
Q

Organophosphorus Compounds MOA

A

irreversible AChE inhibitor

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17
Q

Pyridostigmine Therapeutic Use

A

managment of myasthenia gravis

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17
Q

Pralidoxime MOA

A

acts on phosphorylated esteratic site of AChE - reactives AChE

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18
Q

Pralidoxime Therapeutic Use

A

organophosphate poisoning

19
Q

Atropine MOA

A

competitive cholinergic antagonist
inhibits muscarinic actions of ACh

20
Q

Atropine Therapeutic Effects

A

antidote for cholinergic agonists

21
Q

Atropine Adverse Effects

A

atropine poisoning

22
Q

Treatment for Atropine Poisoning

A

neostigmine
physostigmine

23
Q

Scopolamine MOA

A

cholinergic antagonist

24
Q

Scopolamine Therapeutic Uses

A

prevention of motion sickness

25
Q

Pirenzepine MOA

A

M1 chonlinergic antagonist

26
Q

Pirenzepine Therapeutic Effects

A

reduces gastric acid secretion

27
Q

Tropicamide MOA

A

cholinergic antagonist

28
Q

Tropicamide Therapeutic Uses

A

mydriatic and cyclopegic
treat adhesion between iris and lens

29
Q

Glycopyrrolate MOA

A

synthetic antimuscarinic cholinergic antagonist

30
Q

Glyopyrrolate Therapeutic Uses

A

preanesthetic

31
Q

Homatropine MOA

A

synthetic antimuscarinic

32
Q

Homatropine Therapeutic Uses

A

mydriasis
cycloplegia

33
Q

Ipratropium MOA

A

synthetic antimuscarinic

34
Q

Ipratropium Therapeutic Uses

A

relief if bronchodilation

35
Q

Methantheline MOA

A

synthetic antimuscarinic

36
Q

Propantheline MOA

A

synthetic antimuscarinic

37
Q

Propantheline Therapeutic Uses

A

smooth muscle relaxant

38
Q

Methylatropine MOA

A

synthetic antimuscarnic

39
Q

Methylatropine Therapeutic Uses

A

smooth muscle relaxant

40
Q

Dicyclomine MOA

A

synthetic muscarinic

41
Q

Dicyclomine Therapeutic Uses

A

smooth muscle relaxant

42
Q

Hexamethonium MOA

A

antogonizes nicotinic effect of ACh on autonomic ganglia

43
Q

Trimetaphan MOA

A

competitive nicotinic ganglionic blocker

44
Q

Trimetaphan Therapeutic Uses

A

emergency lowering of BP

45
Q

Nicotine MOA

A

autonomic ganglionic blocker

46
Q

Non-Depolarizing Neuromuscular Blocker MOA

A

competitive inhibition of nicotinic receptors

47
Q

Depolarizing Neuromuscular Blocker MOA

A

acts like ACh - depolarizes the NM junction, peristent depolarization = NM blockade

Pharm I (15 decks)

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