Behavioral Modifiers Flashcards
Clomipramine MOA
tricyclic antidepressant (TCA) - blocks reuptake of serotonin and NE
Clomipramine therapeutic use
separation anxiety
compulsive disorders
urine spraying - cats
anxiety
aggression
Clomipramine adverse effects
sleepiness
Antimuscarinic effects
Clomipramine drug interactions
do not combine with SSRIs
Fluoxetine MOA
SSRI
Fluoxetine therapeutic use in dogs
separation anxiety
compulsive disorders
acral lick granuloma
aggression
Fluoxetine therapeutic uses in cats
urine spraying
inter-cat aggression
compulsive behavior
Fluoxetine adverse effects
sleepiness
decreased appetite
serotonin syndrome
Which species is most sensitive to serotonin syndrome
felines
Selegiline MOA
irreversible MOA-B inhibitor
Selegiline therapeutic use
dogs: cognitive dysfunction, fear/phobias
Selegiline adverse effects
wakefulness
mildk GIT effects
Dexmedetomidine MOA
a2 adrenergic agonist - reduced NE action in locus ceoruleus of brainstem
Dexmedtomidine therapeutic use
sileo gel - noise adversion in dogs
Trazodone MOA
serotonin 2A antagonist and reuptake inhibitor
alpha 1 adrenergic anatagonist
antihistamine properties
Trazodone therapeutic use
adjunct or single agent
anxiety
vet visits (cats)
post-op confinement
Trazodone adverse effects
sleepiness
serotinin syndrome (drug interaction)
Imepitonin MOA
GABA agonist
Imepitonin therapeutic use
noise aversion
anticonvulsant
Imepitonin adverse effects
sedation
polyphagia
Benzodiazepines MOA
GABA-A agonists
Benzodiazepines therapeutic uses
anti-anxiety
Buspirone MOA
5-HT 1A agonist
Buspirone therapeutic use
anxiolytic
Clonidine MOA
a2 agonists
Clonidine therapeutic use
anxiety
fear/phobias
