NSAIDs Flashcards
NSAIDs properties _ inflammation relieve _ pain _ elevated body temp decrease _ by inhibiting platelet aggregation
decrease
mild-moderate
decrease
blood clotting
NSAIDs only treat acute conditions (true/false)
false
acute and chronic
Aspirin and other NSAIDs interfere with the synthesis of _ by non-selectively blocking the synthesis of the enzyme _
prostaglandins
cyclooxyrgenase (COX-1 and COX-2)
Prostaglandins are a group of lipid-like compounds that cause
inflammation pain fever dysmenorrhea thrombus formation
Which COX is responsible for synthesizing “good” prostaglandins that help protect the stomach lining, needed for normal kidney function, needed for normal platelet activity?
COX-1
Which COX is an emergency enzyme that synthesizes “bad” prostaglandins only in response to cell injury
COX-2
What inhibitor has advantages over non-selective NSAIDs and decrease the production of prostaglandins that mediate pain and inflammation?
COX-2
What is the primary adverse effect of NSAID?
GI damage
What are adverse effects with NSAID?
GI damage
hepatotoxicity in pts with liver disease
nephritis in pts with impaired kidney function
Acetaminophen does irritate the gastric lining (true/false)
false
Acetaminophen works at the _ level by inhibiting _ synthesis and less at the _
CNS
prostaglandin
periphery
NSAID cause analgesia (with/without) sedation or hallucinogenic effects
without
Common nonselective examples of NSAID
aspirin ibuprofen (Motrin) indomethacin (indocin) naproxen (naproxen, anaprox, aleve) piroxicam (feldene)
What are the common pathologies that NSAID will treat
arthralgia bone pain bursitis gouty arthritis juvenile rheumatoid arthritis mild pain myalgia osteoarthritis psoriatic arthritis tendinitis
What enzyme can increase the risk of hypertension, thrombosis, atherosclerosis and heart attacks?
COX-2 enzyme
