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Pharmacology > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

A general dysphoric mood as well as a general lack of interest in previously pleasurable activities

A

depression

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2
Q

Depression can be associated with

A

sleep disturbance
anorexia
fatigue
despair

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3
Q

What are the 3 types of depression?

A

reactive
endogenous
bipolar affective disorder

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4
Q

Which type of depression is a response to grief or illness?

a. reactive
b. endogenous
c. bipolar
d. none of the above

A

reactive

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5
Q

Which type of depression is a genetically determined, biochemical disorder?

a. reactive
b. endogenous
c. bipolar
d. none of the above

A

endogenous

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6
Q

This type of depression is associated with bipolar affective disorder

a. reactive
b. endogenous
c. manic-depressive
d. none of the above

A

manic-depressive

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7
Q

Depression is caused by a disturbance in what neurotransmitters?

a. serotonin and ACH
b. ACH and NE
c. E and NE
d. serotonin and NE

A

serotonin and NE

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8
Q

Medication for treating depression is used to _ levels of serotonin in the synpase to result in _ _

A

increase

elevation

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9
Q

Depression will occur with (down regulation/up regulation) of receptors

A

upregulation

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10
Q

Depression is caused by a decreased formation of

A

neurons

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11
Q

Synaptic connections in the _ are (normal/impaired)

A

hippocampus

impaired

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12
Q

The limbic system controls basic _ and _

A

emotions

drives

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13
Q

What can imapir neurogenesis?

A

glucocorticoids

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14
Q

Antidepressants promote _ and the formation of _ connections

A

neurogenesis

synaptic

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15
Q

What drugs can be used to treat depression?

a. glucocorticosteroids
b. Tricyclics, MAO inhibitors, Selective serotonin reuptake inhibitors (SSRI)
c. anti anxiety
d. none of the above

A

Tricyclics, MAO inhibitors, Selective serotonin reuptake inhibitors (SSRI)

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16
Q

Which drug is not selective to serotonin, it blocks the reuptake of amine neurotransmitters into the presynaptic terminals?

a. Tricyclics
b. MAO inhibitors
c. Second Generation Agents
d. all are selective

A

Tricyclics

17
Q

Which drug will block the reuptake of all 3 amines?

a. Tricyclics
b. MAO inhibitors
c. Second Generation Agents
d. none of the above

A

Tricyclics

18
Q

Which drug will block enzymatic destruction of amines in the synaptic cleft?

a. Tricyclics
b. MAO inhibitors
c. Selective serotonin reuptake inhibitors (SSRI)
d. none of the above

A

MAO inhibitors

19
Q

Which drug can dangerously interact with foods that contain tryamine?

a. Tricyclics
b. MAO inhibitors
c. Selective serotonin reuptake inhibitors (SSRI)
d. all of the above

A

MAO inhibitors

20
Q

Which drug will block the reuptake of serotonin?

a. Tricyclics
b. MAO inhibitors
c. Selective serotonin reuptake inhibitors (SSRI)
d. none of the above

A

Selective serotonin reuptake inhibitors (SSRI)

21
Q

Which drugs result in higher levels of serotonin in the synaptic cleft?

A

all

22
Q

what percentage of the neurotransmitters are removed from the cleft by reuptake?

A

50-80%

23
Q

This type of drug will block the enzyme and those out in the periphery for production of NE

A

MAO Inhibitor

24
Q

using an MAO inhibitor, neurotransmitters remain in the _

A

cleft

25
Q

This type of drug is taken if there is no response to other drugs or due to their side effects

A

MAO inhibitors

26
Q

Second generation drugs work to _ the reuptake of monamines but are (more/less) selective

A

block

more

27
Q

Second generation drugs are

A

more rapid onset
more tolerable
safer

28
Q

Side effects with tricyclics and MAO inhibitors

A

sedation
orthostatic hypotension
cardiac arrhythmias
increased seizure risk

29
Q

Side effects with second generation agents

A

nausea
insomnia
tremor
orthostatic hypotension

30
Q

MAO inhibitors can have what kind of adverse effects?

A

CNS excitation

hypertension crisis if taken with sympathomimetic, cheese, wine or other fermented foods

31
Q

What stimulates the release of endogenous E and NE?

A

tryamine

32
Q

tricyclics have been shown to relieve pain when used alone but especially in conjunction with traditional analgesics (True/false)

A

true

33
Q

Rehab concerns with these drugs

A

orthostatic hypotension
sedation/lethargy
suicidal risk

Pharmacology (13 decks)

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