Antidepressants Flashcards
A general dysphoric mood as well as a general lack of interest in previously pleasurable activities
depression
Depression can be associated with
sleep disturbance
anorexia
fatigue
despair
What are the 3 types of depression?
reactive
endogenous
bipolar affective disorder
Which type of depression is a response to grief or illness?
a. reactive
b. endogenous
c. bipolar
d. none of the above
reactive
Which type of depression is a genetically determined, biochemical disorder?
a. reactive
b. endogenous
c. bipolar
d. none of the above
endogenous
This type of depression is associated with bipolar affective disorder
a. reactive
b. endogenous
c. manic-depressive
d. none of the above
manic-depressive
Depression is caused by a disturbance in what neurotransmitters?
a. serotonin and ACH
b. ACH and NE
c. E and NE
d. serotonin and NE
serotonin and NE
Medication for treating depression is used to _ levels of serotonin in the synpase to result in _ _
increase
elevation
Depression will occur with (down regulation/up regulation) of receptors
upregulation
Depression is caused by a decreased formation of
neurons
Synaptic connections in the _ are (normal/impaired)
hippocampus
impaired
The limbic system controls basic _ and _
emotions
drives
What can imapir neurogenesis?
glucocorticoids
Antidepressants promote _ and the formation of _ connections
neurogenesis
synaptic
What drugs can be used to treat depression?
a. glucocorticosteroids
b. Tricyclics, MAO inhibitors, Selective serotonin reuptake inhibitors (SSRI)
c. anti anxiety
d. none of the above
Tricyclics, MAO inhibitors, Selective serotonin reuptake inhibitors (SSRI)
Which drug is not selective to serotonin, it blocks the reuptake of amine neurotransmitters into the presynaptic terminals?
a. Tricyclics
b. MAO inhibitors
c. Second Generation Agents
d. all are selective
Tricyclics
Which drug will block the reuptake of all 3 amines?
a. Tricyclics
b. MAO inhibitors
c. Second Generation Agents
d. none of the above
Tricyclics
Which drug will block enzymatic destruction of amines in the synaptic cleft?
a. Tricyclics
b. MAO inhibitors
c. Selective serotonin reuptake inhibitors (SSRI)
d. none of the above
MAO inhibitors
Which drug can dangerously interact with foods that contain tryamine?
a. Tricyclics
b. MAO inhibitors
c. Selective serotonin reuptake inhibitors (SSRI)
d. all of the above
MAO inhibitors
Which drug will block the reuptake of serotonin?
a. Tricyclics
b. MAO inhibitors
c. Selective serotonin reuptake inhibitors (SSRI)
d. none of the above
Selective serotonin reuptake inhibitors (SSRI)
Which drugs result in higher levels of serotonin in the synaptic cleft?
all
what percentage of the neurotransmitters are removed from the cleft by reuptake?
50-80%
This type of drug will block the enzyme and those out in the periphery for production of NE
MAO Inhibitor
using an MAO inhibitor, neurotransmitters remain in the _
cleft
This type of drug is taken if there is no response to other drugs or due to their side effects
MAO inhibitors
Second generation drugs work to _ the reuptake of monamines but are (more/less) selective
block
more
Second generation drugs are
more rapid onset
more tolerable
safer
Side effects with tricyclics and MAO inhibitors
sedation
orthostatic hypotension
cardiac arrhythmias
increased seizure risk
Side effects with second generation agents
nausea
insomnia
tremor
orthostatic hypotension
MAO inhibitors can have what kind of adverse effects?
CNS excitation
hypertension crisis if taken with sympathomimetic, cheese, wine or other fermented foods
What stimulates the release of endogenous E and NE?
tryamine
tricyclics have been shown to relieve pain when used alone but especially in conjunction with traditional analgesics (True/false)
true
Rehab concerns with these drugs
orthostatic hypotension
sedation/lethargy
suicidal risk
