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Pharmacology > Arthritis > Flashcards

Arthritis Flashcards

1
Q

Which type of arthritis is described as a systemic disorder affecting many different tissues, associated with pain, stiffness, and inflammation of synovial joints, probably an autoimmune disease and bouchards nodes?

a. rheumatoid
b. osteo

A

rheumatoid

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2
Q

Which type of arthritis is described as non systemic, affects articular cartilage, not an autoimmune disease and Heberdens nodes?

a. rheumatoid
b. osteo

A

osteo

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3
Q

Bouchards nodes are on the (proximal/distal) joints

A

proximal

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4
Q

Heberden nodes are on the (proximal/distal) joints

A

distal

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5
Q

What drugs can be used to treat RA?

A

NSAIDs
Glucocorticoids
Disease-modifying antirheumatic drugs

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6
Q

this type of drug is extremely effective antiinflammatory, used when NSAIDs are no longer effective

A

glucocorticoids

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7
Q

this type of drug is used when NSAID and glucocorticoids do not alter the progression of RA

A

disease-modifying antirheumatic

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8
Q

What is the safest DMARD?

a. antimalarial
b. azathioprine
c. gold therapy
d. leflunomide

A

antimalarial

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9
Q

This type of DMARD is an immunosuppressive drug used to prevent tissue rejection following organ transplants

a. antimalarial
b. azathioprine
c. gold therapy
d. leflunomide

A

azathioprine

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10
Q

This type of DMARD is one of the earliest DMARDs but has strong adverse effects

a. antimalarial
b. azathioprine
c. gold therapy
d. leflunomide

A

gold therapy

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11
Q

This type of DMARD is a newcomer, less toxic with fewer side effects

a. antimalarial
b. leflunomide
c. gold therapy
d. methotrexate

A

leflunomide

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12
Q

This type of DMARD is a very popular anti-cancer agent and one of the most effective

a. antimalarial
b. leflunomide
c. gold therapy
d. methotrexate

A

methotrexate

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13
Q

DMARD includes _ which is high in fish oil

A

diet

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14
Q

What hormones are lipid-soluble and pass directly through the cell membrane and into the cytoplasm?

A

steroid complex

thyroid hormone complex

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15
Q

Where do steroid and thyroid hormone complexes attach to a messenger to effect gene activity?

A

the cytoplasm

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16
Q

once gene activity is effected by the steroid and thyroid hormone complex, what occurs?

A

protein synthesis and cellular function

17
Q

What is the natrual glucocorticoid?

A

cortisol

18
Q

Cortisol is synthesized and released by the _ _

A

adrenal cortex

19
Q

Cortisol is released in response to stress caused by

A 
trauma
infection
hemorrhage
food/water deprivation
psychologic stress
20
Q

_ causes the breakdown of muscle proteins so amino acids can be used to synthesize glucose in the liver

A

cortisol

21
Q

What is the primary problem when glucocorticoids are administered over an extended period of time?

A

catabolism of muscle tissue

22
Q 
Glucocorticoids are 
potent _-_ agents
inhibit _ response
enhance _ and water reabsorption 
alter _ and _
A

anti-inflammatory
immune
renal Na+
behavior and mood

23
Q

How do corticosteroids effect muscle?

A

interfere with muscle protein synthesis by altering the cells ability to retain amino acids

24
Q

What is characterized by proximal muscle weakness affecting ambulation and functional ability?

A

steroid myopathy

25
Q

OA more commonly seen than RA (true/false)

A

true

26
Q

which type of arthritis has no apparent extrinsic cause?

A

primary OA

27
Q

which type of arthritis is caused by trauma, infection and metabolic disease?

A

secondary OA

28
Q

How can OA be treated?

A 
PT 
weight loss
arthroplasty 
NSAIDs
glucocorticoids 
acetaminophen
DMOAD
29
Q

An intra-articular injection of hyaluronan to restore normal synovial fluid viscosity

A

viscosupplementation

30
Q

side effects of glucocorticoids

A

catabolic effects on skin, muscle, tendon and bone

avoid causing fx, soft tissue injury, skin breakdown

Pharmacology (13 decks)

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