NSAID, Acetaminophen, DMARDs and Drugs used in Gout

Question 1

Classification of NSAISs

Answer 1

Salicylates - irreversible
Non Selective NSAIDs - reversible
COX 2 Selective

Question 2

Salicylates

Answer 2

Aspirin

Question 3

Non Selective NSAIDs

Answer 3

Piroxicam
Ketorolac
Ibuprofen
Indomethacin

Question 4

COX 2

Answer 4

COXIBs

Question 5

Non Selective, Irreversible COX 1 and COX 2 inhibitor, Reduces Platelet production of TXA2 -> Red platelet aggregation

Answer 5

Aspirin

Question 6

Aspirin dosage that decreases platelet aggregation

Follows first order kinetics

Answer 6

Low range <300

Question 7

Aspirin dosage that is Antipyretic and Analgesic

Answer 7

Intermediate Dose 300-2400

Question 8

Aspirin dosage that is anti-inflammatory

Follows Zero order kinetics

Answer 8

High Dose 2400-4000

Question 9

Aspirin Toxic Dose

Answer 9

150 mg/kg or 21 500 mg tabs

Question 10

Aspirin Lethal Dose

Answer 10

30 g 60 500 mg tabs

Question 11

Acid base d/o of aspirin

Answer 11

HAGMA + Respiratory Alkalosis

Question 12

Uncoupler o oxidative phosphorylation
Associated with Reye’s syndrome
Prevents uric acid excretion
Reduces risk of Colon CA

Answer 12

Aspirin

Question 13

NSAID Non Selective
Reversible COX 1 and COX 2 inhibitor
Inhibits Prostaglandin synthesis
Less GI Bleeding than Aspirin

Answer 13

Ibuprofen

Question 14

Prevents NSAID induced gastritis

Answer 14

Misprostol

Question 15

Used to close PDA

Answer 15

Ibuprofen and Indomethacin

Question 16

Interferes with ASA’s antithrombotic action

Answer 16

NSAIDs

Question 17

IV NSAID
Non selective reversible COX 1 and COX 2 inhibitor
Post surgical analgesic control, NOT for anti-inflammatory

Answer 17

Ketorolac

Question 18

Restricted time of use of Ketorolac

Answer 18

72 hours

Question 19

Non selective reversible COX 1 and COX 2 inhibitor. Inhibits prostaglandin synthesis
Anti-inflammatory (Gout, Arthritis, Ankylosing Spondylitis)
Closure of PDA
COX1>COX2
Has GREATER ANTIINFLAMMATORY EFFECT compared to other NSAIDs

Answer 19

yyIndomethacin

Question 20

Selective COX-2 inhibitor
Has prothrombotic affect -> MI, Stroke
COX2>COX1

Answer 20

Celecoxib

Question 21

Preferentially COX2 selective inhibitor

Answer 21

Meloxicam

Question 22

COX 3 inhibitor
Increased Hepatotoxicity with alcohol
Does not cause Reye’s syndrome

Answer 22

Paracetamol

Question 23

COX 3 inhibitor Interstitial nephritis

Answer 23

Phenacetin

Question 24

Antidote of Paracetamol

Answer 24

N - Acetylcysteine

Question 25

Toxic Dose of Paracetamol

Answer 25

150 mg/kg 21 tabs

Question 26

Lethal Dose of Paracetamol

Answer 26

15g 30 tabs