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Pharma > Drugs for Coagulation Disorders > Flashcards

Drugs for Coagulation Disorders Flashcards

1
Q

Antiplatelet, Anti inflammatory, COX Inhibitor
Non selective COX 1 & 2 Inhibitor
Used to prevent thrombosis and inflammation
SE: HAGMA, Gatrointestinal Toxicity

A

Aspirin

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2
Q

Uncoupler of oxidative phosphorylation
Associated with Reye syndrome in children
NOT used in Gout

A

Aspirin

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3
Q

SAMTER Triad

A

Asthma
Aspirin Sensitivity
Nasal Polyps

SAM the ASTHMATIC is SENSITIVE to NASAL POLYPS

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4
Q

Acid Base abnormality for Salicylate poisoning

A

Respiratory Alkalosis with HAGMA

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5
Q

Difference bet presentation of Aspirin intoxication in Adults and Children

A 
Adults = Mixed acid base disorder (Respiratory alkalosis with HAGMA)
Kids = Pure acid base disorder (HAGMA only)
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6
Q

GPIIa/IIIa inhibitor
Used in PCI to prevent thrombosis
Prevents restenosis, reinfarction and death

A

ABCiximab

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7
Q

Antiplatelet (Theinopyridine), ADP inhibitor
Irreversibly inhibits binding of ADP platelet receptors reducing platelet aggregation

Has additive effect with Aspirin

A

Clopidogrel

Ticlopidine - Most side effects

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8
Q

GI and Hemorrhagic SE are common

A

Ticlopidine

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9
Q

Thienopyridine that inhibits ADPsubtype P2Y -> Allosteric Antagonist

A

Ticagrelor

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10
Q

Antiplatelet, PDE inhibitor
Inhibits Phosphodiesterase III and increase cAMP

Used in prevention of Thromboembolic complications of cardiac valve replacement

Never used alone always with Aspirin

A

Dipyridamole

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11
Q

Intermittent Claudication

Contraindicated in HF

A

Cilostazol

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12
Q

Indirect thrombin inhibitors

A

Heparin
Enoxaparin
Coumarin derivatives (Warfarin)

Indirect war in ox’s hip

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13
Q

Direct thrombin inhibitors

A

Lepirudin

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14
Q 
Large acidic
Parenteral ->Acts on Blood
Rapid Onset -> Acute
Activates Antithrombin III
Monitored by PTT
Can be used in Pregnancy
A

Heparin

Malaki at maugat ang hip ng auntie ni brad pitt kaya pwede mabuntis

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15
Q

Antidote for Heparin Overdose

A

Protamine

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16
Q 
Small Lipid Soluble
Oral -> Acts on Liver
Slow -> Chronic
Impairs Vit K dependent 9,10,7,2
Monitored by PT
Cannot be used by Pregnant
A

Warfarin

Palaaway, Maliit, mabagal, mataba at kain ng kain ang pet ko na si K kaya bawal mabuntis

17
Q

Antidote for Warfarin

A

Vitamin K (Slow), FFP (Fast)

18
Q

DOC for Anticoagulation during pregnancy

19
Q

SE Heparin

A

Osteoporosis

20
Q

Potentiates effect of antithrombin III on Factor Xa
Less risk of Thrombocytopenia
DOES NOT require aPTT monitoring
Protamine Sulfate only partially effective in reversing

A

EnoXAparin

21
Q

Binds to Thrombin’s active site
Anticoagulation in patients with Heparin induced Thrombocytopenia, Percutaneous coronary angioplasty (with Aspirin)
Monitored with aPTT
SE: Effect prolonging antibodies

A

Lepirudin/ Dabigatran

22
Q

Oral Direct Factor for Xa inhibitor
Prevention of Stroke Patients with Atrial Fib
Does not require monitoring, No antidotes
Used esp after hip or knee surgery

A

Rivaroxaban/ Apixaban

23
Q

Anticoagulant overlap

A

to bypass initial prothrombotic effect of warfarin

24
Q

CY P450 Inducers

A

Ethel Booba Takes Phen Phen and Refuses Greasy Carb Shakes

Ethanol
Barbiturates
Phenytoin
Rifampicin
Griseofulvin
Carbamazepine
St. John's Wort/ Smoking
25
Q

CY P450 Inducers

A

Ethel Booba Takes Phen Phen and Refuses Greasy Carb Shakes

Ethanol
Barbiturates
Phenytoin
Rifampicin
Griseofulvin
Carbamazepine
St. John's Wort/ Smoking
26
Q

CY P450 Inhibitors

A

Inhibitors stop Cyber Kids from Eating the Queen’s GRApefruit

Isoniazid
Sulfonamides
Cimetidine
Ketoconazole
Erythromycin
Quinidine
Grapefruit
Ritonavir
Amiodarone
27
Q

Chemical Antagonist of Heparin

Used for Heparin Overdose

A

Protamine Sulfate

28
Q

Thrombolytic
Tissue plasminogen activator analog, coverts plasminogen to plasmin
For Acute Myocardial infarction
LOSS of effectiveness on 2nd use

A

Alteplase/ Streptokinase/ Urokinase

29
Q

Antidote for Thrombolytics (Alteplase, Streptokinase)

A

Aminocaproic Acid

30
Q

Forms complex with endogenous plasminogen catalyzing conversion of plasminogen to plasmin

A

Streptokinase

31
Q

Contraindication for Thrombolysis

A 
CVD Bleed anytime
CVD Infract within past year
HPN >180/110
Aortic Dissection
Active Internal Bleeding
32
Q

Aminocaproic Acid, Antiplasmin Drug
Competitively inhibits plasminogen activation by inhibiting tPA

Prevention and treatment of ACUTE BLEEDING Episodes

A

Tranexamic Acid

33
Q

Contraindicated in DIC

A

Tranexamic Acid

34
Q

Endogenous Vitamin
Antidote to Warfarin
Prevention of hemorrhagic diathesis in NB

A

Vit K
Vit K2 - Menaquinone
Vit K3- Menadione -> Never used in Therapeautics
Phytomenadione

35
Q

ADH Agonist
Vasopressin V2 Receptor AGONIST
Increases Factor 8 activity in Haemophilia A and vWF disease

A

Desmopressin/ Vasopressin

Pharma (20 decks)

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