Diuretics Flashcards

1
Q

Site of Carbonic Anhydrase Inhibitors

A

Proximal Convoluted Tubule

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2
Q

Carbonic Anhydrase Drug

A

“Zolamides”

Acetazolamide

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3
Q

Use of Acetazolamide

A

DiarrheaGlaucoma
Edema with Alkaslosis
Mountain Sickness

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4
Q

SE Acetazolamide

A

Hyperchloremic metabolic acidosis

Hepatic encephalopathy

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5
Q

NAGMA

A
HARD UP
Hyperalimentation
Acetazolamide
RTA
Diarrhea
Ureteral diversion
Pancreatic Fistula
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6
Q

Site of action Loop Diretics

A

Thick Ascending Loop of Henle

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7
Q

Decrease efficacy of Loop Diuretics

A

NSAID

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8
Q

Prototype Loop Diuretic

A

Furosemide

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9
Q

Loop Diuretics inhibit

A

Na/K/2Cl transporter

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10
Q

Uses Loop Diuretic

A

Anion Overdose, Hypercalcemia

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11
Q

SE Loop Diuretic

A

Hypokalemic metabolic alkalosis

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12
Q

Synergistic ototoxicity with Furosemide

A

Aminoglycosides

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13
Q

Furosemide Toxicity

A
OH DANG
Ototoxicity
Hypokalemia
Dehydration
Sulfa Reaction
Nephritis
Gout
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14
Q

Site of Thiazide Diuretics

A

DCT - Na/Cl transporter

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15
Q

Diuretic for Hypercalciuria and Nephrogenic DI

A

Thiazides - Hydroxychlorothiazide

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16
Q

Thiazide Toxicity

A
Hyper GLUC
Hyper Glycemia
Hyper Lipidemia
Hyper Uricemia
Hyper Calcemia
17
Q

Steroid inhibitors of cytoplasmic aldosterone receptor in cortical collecting ducts

A

Spirinolactone

18
Q

K Sparing diuretics

A
K STAE
Spirinolactone
Triamterene
Amiloride
Epleronone
19
Q

Gynecomastia drugs

A
Spirinolactone
Digoxin
Cimetidine
Alcohol
Ketoconazole
20
Q

Potassium Sparing, Na blocker
Inhibits ENaC
Used for Hypokalemia

21
Q

Retains Water in the Tubule

A

Osmotic Diuretics, Mannitol

22
Q

For Rhabdomyolysis, Increase Intracranial pressure, Acute Glaucoma

A

Osmotic Diuretics - Mannitol

23
Q

AE of Mannitol

A

Transient volume expansion

24
Q

Site of ADH action

A

Medullary Collecting Ducts

25
Agonist V1 and V2 | Insertion of Aquaporin Water Channels in CD
Vasopressin
26
For central diabetes insipidus, Nocturnal enuresis, Hemophilia and vWD Disease
Vasopressin
27
Increases Factor VIII
Vasopressin
28
ADH not given in pregnancy as it inc uterine pressure
Telopressin
29
V1 AND V2 Antagonist
Conivaptan
30
For SIADH and Hyponatremia
Conivaptan
31
SE of Conivaptan
Nephrogenic DI | Bone and Teeth Abnormalities
32
Dual endothelin receptor agonist for pulmonary HPN
Bosentan
33
Acts in metab of lipid and CHO, has protective effects in cardiac and endothelial dysfunction
L Carnitine
34
Sympatholytic anti HPN, acts as a A1 antagonist and 5HT1A agonist
Urapidil
35
Stabilized cell membranes and reduces free radicals
Citicoline
36
B2 adrenoceptor agonist, tx of premature labor and Raynauds
Isoxuprine