Adrenergic pharmacology + Sympathomimetics Flashcards

1
Q

Inhibits Tyrosine to DOPA

A

Metryrosine

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2
Q

Vesicular Transport (Storage) inhibited by

A

Reserpine

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3
Q

Release by entry of Ca triggers among SNARE Proteins

A

inhibited by: Guanethedine

promoted by: Amphetamine and Tyramine

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4
Q

Diffusion and reuptake via NET and DAT is inhibited by

A

TCA and Cocaine

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5
Q

metabolism b MAO and COMT into metanephrines and VMA inhibited by

A

MAOi and COMTi

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6
Q

Synthesis Inhibition

A

Metyrosine

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7
Q

Storage Inhibition

A

Reserpine

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8
Q

Release Inhibition

A

Guanethedine

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9
Q

Metabolism Inhibition

A

MAOi and COMTi

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10
Q

Reuptake Inhibition

A

Cocaine, TCA

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11
Q

Contriction

A

a1

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12
Q

Dec NT release

A

a2

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13
Q

Inc HR, Inc Renin

A

B1

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14
Q

Relaxation

A

B2

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15
Q

Lipolysis

A

B3

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16
Q

Renal Vasodilation

A

D1

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17
Q

Inhibits Adeyltae Cyclase

A

D2

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18
Q

Activates a and B receptors

B2 - Bronchodilation

A

Epinephrine

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19
Q

Activates a and B receptors

(-) Bronchodilation

A

Norepinephrine

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20
Q

DOC Cardiac Arrest

A

Epinephrine

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21
Q

DOC Anaphylaxis

A

Epinephrine - In the pines arrest Ana

22
Q

Neurogenic and Cardiogenic Shock (Last Resort)

A

Norepinephrine

23
Q

SE: Norepinephrine

A

Extreme Vasospasm

24
Q

Reflex Bradycardia

A

Norepinephrine

25
Cardiogenic Shock and Heart Failure
Dopamine
26
binds to a1,b1,D1 receptors
Dopamine
27
Low dose dopamine (1-5)
D1
28
Medium dose (5-15)
B1
29
High dose (>15)
a1
30
Sympathomimetic for Asthma
Isoproterenol - Adrenergic (Ipratropium - Muscarinic)
31
a1 agonist
Phenylephrine - a1 - vasoconstriction, inc BP
32
a1, nasal decongestant, drug induced hypotension, mydriasis without cycloplegia
Phenylephrine
33
SE Phenylephrine
Rebound nasal decongestion
34
DOC for a1 agonist overdose
Phentolamine
35
a1 avoided in 1st trimester possible risk of gastroschisis
Pseudophedrine
36
a2 agonists
Methydopa Clonidine Apraclonidine
37
a2 agonist Hypertension, Cancer, Opioid Pain
Clonidine
38
a2 agonist, Preeclampsia, Gestational HPN
Methyldopa
39
a2 agonist sedative - Conscious sedation
Dexmedetomidine
40
a2 agonist muscle relaxant
Tizanidine
41
a2 for glaucoma
Apraclonidine
42
Rhinitis medicamentosa
SE of Phenyleprine
43
Antidote for a2 toxicity
Phentolamine
44
Preeclamptic, -> Methydopa
Hemolytic anemia, + Coombs
45
b1 agonist Heart Failure Cardiogenic shock
Dobutamine
46
Cardiac Stress testing
Dobutamine
47
SE Eosinophilic Myocarditis
Dobutamine
48
B2 agonist | Acute Asthma - DOC
Salbutamol
49
B2 agonist | Tocolytic
Terbutaline
50
Vasodilator in Raynaud's | Maternal Pulmonary edema
Isoxuprine
51
Nasal vasoconstrictor Appetite Suppressant SE: Hemorrhagic stroke
Phenypropanolamine