Anemia and Hematopoietic Growth Factors

Question 1

Hematopoietic growth factor
Required for the Biosynthesis of Heme
For Iron deficiency anemia, Iron supplementation
SE: Black Stools
Acute Overdose: Necrotizing gastroenteritis
Chronic iron overdose: Hemochromatosis

Answer 1

Ferrous Sulfate

Question 2

Highest Oral Iron Prep

Answer 2

Fe Carbonyl/ Carbonyl Iron

Question 3

Lowest Oral Iron Prep

Answer 3

Fe Gluconate

Question 4

Antidote for Acute Iron Intoxication

Answer 4

Deferoxamine (De FE)

Question 5

Triad of Hemochromatosis

Answer 5

Cirrhosis, DM, Skin Pigmentation

Cirr is a Diabetic Pig

Question 6

Tx:

Answer 6

Phlebotomy

Deferiprone/ Deferasirox

Question 7

Chelates excess Iron

For acute iron poisoning and Hemochromatosis

Answer 7

Deferoxamine

Question 8

Acute Iron Toxicity

Answer 8

Deferoxamine

Question 9

Chronic Iron Toxicity

Answer 9

Deferasirox/ Deferiprone

Question 10

Megaloblastic Anemia + Neurologic defects

Answer 10

Vit B12 Deficiency

Question 11

Neurologic manifestations of Vit B12 Deficiency

Answer 11

Ataxic
Position
Vibratory
Spasticity

Attack the Vibrating Spa’s Position

Question 12

Vit B12 Supply in the liver

Answer 12

5 years

Question 13

Hematopoietic Growth Factor
Cofactor req for essential enzymatic reactions
Used for Megaloblastic (Pernicious anemia, Gastric Resection)

Answer 13

Cyanocobalamin

T1/2 : Hydroxycobalamin > Cyanocobalamin

Question 14

Hematopoietic Growth Factor
Precursor for essential donor
For Megaloblastic Anemia, Prevention of Neural tube defects (spina bifida)

Answer 14

Folic Acid

Question 15

Agonist of erythropoietin receptors expressed by red cell progenitors

Used in anemia assoc with CKD, prevention of transfusion of preoperative px

SE: Red Cell aplasia

Answer 15

Epoetin Alfa

Question 16

Performance enhancing drug

Answer 16

Epoetin Alfa

Question 17

Myeloid growth factor
Accelerates neutrophil recovery -> reduces incidence of infection

Used for Neutropenia associated with chemotherapy, myelodysplasia and aplastic anemia

SE: Bone pain

Answer 17

Filgrastim

Pegfilgrastim has a higher T 1/2

Question 18

Megakaryocyte growth factor
Activates IL - 11
Secondary Prevention of Thrombocytopenia

Answer 18

Oprelvekin

Ovechkin 11 mega plates

Question 19

Small molecule thrombopoietin

For ITP

Answer 19

Eltromobopag

Question 20

Hematopoeitic stem cell mobilizer

For mobilization of Hematopoietic stem cells in NHL and MM

Answer 20

Plerixafor

Question 21

Thrombopoietin receptor agonist

Answer 21

Romiplostim