Antihypertensives Flashcards
Target BP no comorbidities
140/90
Target BP DM and CKD
130/80
Antihypertensive agents for pregnant women
Nifedipine
Methyldopa
Labetalol
Knife in a Methlab
First DOC for Pregnant HPNives
Methydopa
2nd line DOC for pregnant HPNives
Labetalol
Effective as monotherapy or as add on with methydopa in chronic hypertension in pregnant women
Hydralazine
Hypertensives not recommended for pregnancy
ACEi or ARBs
1st Line Antihypertensives
Thiazide Diuretics
Inhibirs Na/Cl treansporter in the DCT
Thiazide diuretics
Thiazide that crosses the cord blood and passes the placenta
Metolazone
Antihypertensive diuretic that is also used for Nephrogenic Diabetes Insipidus
Thiazide Diuretics
Inhibits Na/K/2Cl transporter
Loop Diuretics - Furosemide
Antihypertensive diuretic also used for Anion overdose
Loop Diuretic
Diuretic with AE of Hypocalcemia
Loop Diuretic
Loop diuretic that can be given to sulfur allergy
Ethacrynic acid
AE:
Hyoicalcemia
Ototoxicity
Nephritis
Loop Diuretics
a2 agonist
Hypertension, Cancer Pain, Opioid Withdrawal
Clonidine
a2 agonist
Preeclampsia
Sedation, Positive Coombs
Methyldopa
Ganglion Blocker
Hypertension - obsolete, Hypertensive Emergencies
Postural Hypertension
Hexamethonium
Blocks VMAT
Hypertension - Obsolete
Depression, Suicidal Ideation
Reserpine
Inhibit vesicular release of NE
Hypertension - Obsolete
Depression, Suicidal Ideation
Guanethidine
Selective a1 blocker
BPH, HPN
Prazosin
Blocks b1 and b2, Reduces Renin Release
Angina Prophylaxis, HPN, Glaucoma, Performance anxiety, Hypethyroidism
Propanolol
Drugs used to control BP in Pheocrhromocytoma
Phenoxybenzamine
Phentolamine
Carvedilol
Labetalol
Alters intracellular Ca
For preeclampsia
Drug induced Lupus
Hydralazine
Opens K channels
Hypertension, Alopecia
Hypertrichosis, Hirsutism
Minoxidil
Calcium channel Blocker - Non dihydropyridine
Hypertension, OPD DOC of Supraventricular Tachycardia
Verapamil
SE of Verapamil
Gingival Hyperplasia
Dihydropyridine CCB
Angina, Hypertension
Pretibial edema
Nifedipine
SE of Pretibial edema
Nifedipine
Relaxes both Venous and Arteriolar, inc NO -> Inc cGMP
Hypertensive Emergency
Cyanide Toxicity
Nitroprusside
Vasodilation of Efferent and Afferent arterioles
Hypertensive Emergency
HYPOKALEMIA
Fenoldopam
ACE inhibitor
HPN, Post MI
SE: COUGH
Capopril
Blocks Angiotensin
For Hypertension
Hypoglycemia
Losartan
Anti HPN, Contraindicated in Pregnancy
ACEi and ARBs
Reduces aldosterone -> Hypokalemia
ARBs/ ACEis
Inhibits Renin
Hypertension
Increase serum Crea
Alikskiren
Alis ka renin
Antihypertensive, subarachnoid hemorrhage
Nimodipine
Antidote for the Cyanide toxicity of Nitroprusside
Amyl nitrate
Rising BP and rapidly progressing end organ damage
Malignant Hypertension
Tx of Malignant HPN
Vasodilators + B Blockers + Diuretics
Virgil Ban Dijk