Histamine, Serotonin and Ergot Derivatives Flashcards
Excess Histamine Detected through
Imidazole Acetic Acid in the Urine
Smooth Muscle
Inc IP3 DAG
H1
Stomach, Heart, Mast Cells
Inc cAMP
H2
Nerves, Brain
Dec cAMP
H3
Leukocytes
Dec cAMP
H4
Pain and Itching
Broncoconstriction, Vasodilation, Local Edema
H1
Gastric Acid Secretion, Cardiac stimulation
H2
Modulation of NTs
H3
Leukocyte chemotaxis
H4
Blocks Peripheral CNS H1 plus a and M receptor block
Anti motion sickness
1st Gen H1 - Diphenydramine
H1 block
No autonomic or anti motion sickness effects
2nd Gen H1 - Cetirizine
H1 Anti emetic
Promethazine -H1 1st gen
Serotonin Syndrome
Cyproheptadine - H1 1st gen
Has Alpha 1 blocking and local anesthetic affect
1st Gen H1
Fatal arrhythmias from interaction with Azoles/Erythromycin
Terfenadine/ Astemizole