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Pharma > Drugs used in Dyslipidemia > Flashcards

Drugs used in Dyslipidemia Flashcards

1
Q

HMG CoA inhibitor

A

Statins

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2
Q

Statins

A

HmG CoA inhibitor
Increased hepatic cholesterol uptake
Increased high affinity LDL receptors
Decreased LDL levels

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3
Q

Hypercholesterolemia
ACS
Ischemic Stroke

A

Statins`

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4
Q

Prodrug statins

A

Simvastatin
Lovastatin

Production loves simming

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5
Q

Why are statins used in the management of ACS

A

because they stabilize atherosclerotic plaques

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6
Q

Binds Bile acids preventing their absorption

A

Bile Resins

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7
Q

Hypercholesterolemia (High LDL)
Pruritus in Cholestasis
Digitalis Toxicity

A

Bile Acid Resins

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8
Q

SE Bile acid resins

A

Steatorrhea

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9
Q

Avoided in px with diverticulitis

A

Bile Acid Resins

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10
Q

Increases TGs and VLDL

A

Bile Acid resins - avoid with patients with high TAGs

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11
Q

Inhibits NPC1L1

A

Ezetimibe - Sterol absorption blocker

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12
Q

Used for Hypercholesterolemia, Phytosterolemia

A

Ezetimibe and Sitosterol (Cholesterol Absorption blockers)

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13
Q

AE: Myositis and Hepatotoxicity if used with statins

A

Ezetimibe

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14
Q

Synergistic effect with statina

A

Ezetimibe

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15
Q

Cholesterol Analog

A

Sitosterol

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16
Q

Most effective agent in increasing HDL levels

A

Niacin

17
Q

AE: Flushing and Acanthosis Nigricans

A

Niacin

18
Q

Used in Hypercholesterolemia (High LDL/VLDL, low HDL)

A

Niacin

19
Q

Reduces flushing from Niacin

A

Aspirin

20
Q

Avoided in PUD
Potentiates antihypertensives
decrease fibrinogen and increases t-pa

A

Niacin

21
Q

Drugs that causes Flushing

A 
Nice Call on the Van Ad
Niacin
Calcium Channel Blockers
Vancomycin
Adenosine
22
Q

DOC Hypertriglyceridemia

A

Fibrates

23
Q

Activates PPAR - alpha -> inc lipoprotein lipase

Lowers TG, Inc HDL

A

Fibrates (FULL - Fibrates Upregulates Lipoprotein Lipase)

24
Q

AE Fibrates

A

Inc risk of cholesterol gallstones

25
Q

Increases risk of myopathy and rhabdomyositis when used with statins

A

Fibrates

26
Q

Familial Hypercholesterolemia

A

Nice and Easy State
Statin + Niacin
Statin + Ezetimibe

27
Q

Familial Combined Hypercholesterolemia

A

Nirest Fista
Niacin + Resin
Fibrates + Statin

28
Q

Inc risk of cholestasis

A

Fibrate + Resin (FIRE)

29
Q

Impaired statin absorption

A

Statin + Resin

30
Q

Inc risk for Rhabdomyolysis and Myopathy

A

Statin + Fibrate

31
Q

Antioxidant, inc rate of LCL catabolism

Lower LDL and HDL

A

Probubucol

Pharma (20 decks)

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