Drugs used in Dyslipidemia Flashcards
HMG CoA inhibitor
Statins
Statins
HmG CoA inhibitor
Increased hepatic cholesterol uptake
Increased high affinity LDL receptors
Decreased LDL levels
Hypercholesterolemia
ACS
Ischemic Stroke
Statins`
Prodrug statins
Simvastatin
Lovastatin
Production loves simming
Why are statins used in the management of ACS
because they stabilize atherosclerotic plaques
Binds Bile acids preventing their absorption
Bile Resins
Hypercholesterolemia (High LDL)
Pruritus in Cholestasis
Digitalis Toxicity
Bile Acid Resins
SE Bile acid resins
Steatorrhea
Avoided in px with diverticulitis
Bile Acid Resins
Increases TGs and VLDL
Bile Acid resins - avoid with patients with high TAGs
Inhibits NPC1L1
Ezetimibe - Sterol absorption blocker
Used for Hypercholesterolemia, Phytosterolemia
Ezetimibe and Sitosterol (Cholesterol Absorption blockers)
AE: Myositis and Hepatotoxicity if used with statins
Ezetimibe
Synergistic effect with statina
Ezetimibe
Cholesterol Analog
Sitosterol
Most effective agent in increasing HDL levels
Niacin
AE: Flushing and Acanthosis Nigricans
Niacin
Used in Hypercholesterolemia (High LDL/VLDL, low HDL)
Niacin
Reduces flushing from Niacin
Aspirin
Avoided in PUD
Potentiates antihypertensives
decrease fibrinogen and increases t-pa
Niacin
Drugs that causes Flushing
Nice Call on the Van Ad Niacin Calcium Channel Blockers Vancomycin Adenosine
DOC Hypertriglyceridemia
Fibrates
Activates PPAR - alpha -> inc lipoprotein lipase
Lowers TG, Inc HDL
Fibrates (FULL - Fibrates Upregulates Lipoprotein Lipase)
AE Fibrates
Inc risk of cholesterol gallstones
