Neurology- Neuromuscular Disease Flashcards
MS, ALS, GBS, MG, LEMS, muscular dystrophy, Werding Hoff
1
Q
Paraneoplastic syndromes cause muscle weakness
A
Myasthenia gravis
LEMS
Dermatomyositis
Paraneoplastic myelopathy of the spinal cord
2
Q
Myasthenia gravis
A
Autoantibodies against nicotinic acetylcholine receptors in the POSTSYNAPTIC membrane.
3
Q
S&S myasthenia gravis
A
Fluctuating muscle weakness ocular (ptosis, diplopia), bulbar (dysphagia, dysarthria) Facial, neck and limb weakness WORSE with REPETITION
4
Q
LEMS
A
antibodies targeted against the PRESYNAPTIC membrane
5
Q
S&S LEMS
A
Proximal limb weakness Cranial nerve involvement Autonomic dysfunction (dry mouth, ED) ↓ DTR temporary IMPROVEMENT with REPETITION
6
Q
Follow up testing on myasthenia gravis
A
Chest imaging to evaluate for thymoma and possible planning of thymectomy
