Immunology- Immune Reactions

Question 1

S&S anaphylaxis to blood transfusion

Answer 1

Within minutes 
Andgioedema
Hypotension
Shock 
Respiratory Distress

Question 2

Cause of anaphylaxis to blood transfusion

Answer 2

Recipient anti-IgA antibodies directed against donor blood IgA

Question 3

S&S acute hemolytic transfusion reaction

Answer 3

Within 1 hr
Fever
DIC
Flank pain/ Acute renal failure 
Hemoglobinuria 
Positive Coombs

Question 4

Mechanism acute hemolytic transfusion reaction

Answer 4

ABO incompatibility

Question 5

S&S Febrile non hemolytic transfusion reaction

Answer 5

1-6hrs

Fever & Chills

Question 6

Mechanism febrile nonhemolytic transfusion reaction

Answer 6

Cytokine accumulation during blood storage

Question 7

Mechanism urticarial transfusion reaction

Answer 7

Recipient IgE against blood product component. 2-3hrs

Question 8

S&S transfusion related acute lung injury

Answer 8

Within 6hrs
REspiratory distress
Noncardiogenic pulmonary edema
Bilateral pulmonary infiltrates

Question 9

Mechanism transfusion related acute lung injury

Answer 9

donor anti-leukocyte antibodies

Question 10

S&S delayed hemolytic transfusion reaction

Answer 10

Days-weeks
Asymptomatic
Hemolytic anemia
Positive Coombs

Question 11

Mechanism delayed hemolytic transfusion reaction

Answer 11

Anamnestic antibody response

immune activity following exposure to a previously encountered antigen

Question 12

S&S graft vs host

Answer 12

Within weeks
Rash
Fever
GI
Pancytopenia

Question 13

Mechanism graft vs host

Answer 13

Donor T lymphocytes