Neurology- Malignancy

Question 1

Neurofibromatosis 1

Answer 1

Autosomal dominant mutation to NF1 tumor suppressor gene on chromosome 17 which codes for neurofibromas

Question 2

S&S NF1

Answer 2

Cafe-au-lait spots
Multiple neurofibromas
Lisch Nodules
Optic pathway glioma

Question 3

Neurofibromatosis 2

Answer 3

autosomal dominant mutation to NF2 tumor supressor gene on chromosome 22 which codes for merlin protein.

Question 4

S&S NF2

Answer 4

Bilateral acustic neuromas/ vestibular schwannomas